Abstract:
:The unassigned open reading frame YDL142c was identified to code for cardiolipin synthase, Cls1p. A cls1 deletion strain is viable on glucose, galactose, ethanol, glycerol and lactate containing media, although the growth rate on non-fermentable carbon sources is decreased. Mitochondria of the cls1 mutant are devoid of cardiolipin but accumulate the cardiolipin precursor phosphatidylglycerol when grown on non-fermentable carbon sources. Specific activity of phosphatidylglycerolphosphate synthase in cls1 is reduced to 30-75% of the wild-type level. Amounts of mitochondrial cytochromes and activity of cytochrome c oxidase, however, are not affected in the cls1 deletion strain. Collectively, these data indicate that cardiolipin is not essential for aerobic growth of Saccharomyces cerevisiae.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tuller G,Hrastnik C,Achleitner G,Schiefthaler U,Klein F,Daum Gdoi
10.1016/s0014-5793(97)01525-1subject
Has Abstractpub_date
1998-01-02 00:00:00pages
15-8issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(97)01525-1journal_volume
421pub_type
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