The RhoA transcriptional program in pre-T cells.

Abstract:

:The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors. The data show that RhoA plays a specific and essential role in pre-T cells because it is required for the expression of transcription factors of the Egr-1 and AP-1 families that have critical functions in thymocyte development. Loss of RhoA function in T cell progenitors causes a developmental block that pheno-copies the consequence of losing pre-TCR expression in Recombinase gene 2 (Rag2) null mice. Transcriptional profiling reveals both common and unique gene targets for RhoA and the pre-TCR indicating that RhoA participates in the pre-TCR induced transcriptional program but also mediates pre-TCR independent gene transcription.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Mullin M,Lightfoot K,Clarke R,Miller M,Lahesmaa R,Cantrell D

doi

10.1016/j.febslet.2007.07.077

subject

Has Abstract

pub_date

2007-09-04 00:00:00

pages

4309-17

issue

22

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(07)00858-7

journal_volume

581

pub_type

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