Abstract:
:The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors. The data show that RhoA plays a specific and essential role in pre-T cells because it is required for the expression of transcription factors of the Egr-1 and AP-1 families that have critical functions in thymocyte development. Loss of RhoA function in T cell progenitors causes a developmental block that pheno-copies the consequence of losing pre-TCR expression in Recombinase gene 2 (Rag2) null mice. Transcriptional profiling reveals both common and unique gene targets for RhoA and the pre-TCR indicating that RhoA participates in the pre-TCR induced transcriptional program but also mediates pre-TCR independent gene transcription.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mullin M,Lightfoot K,Clarke R,Miller M,Lahesmaa R,Cantrell Ddoi
10.1016/j.febslet.2007.07.077subject
Has Abstractpub_date
2007-09-04 00:00:00pages
4309-17issue
22eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00858-7journal_volume
581pub_type
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