Abstract:
:C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) in skeletal muscle cells. In parallel with the activation of AMPK, CTRP6 induces the phosphorylation of acetyl coenzyme A carboxylase (ACC) and fatty acid oxidation in myocytes. Thus, CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lee W,Kim MJ,Park EJ,Choi YJ,Park SYdoi
10.1016/j.febslet.2010.01.040subject
Has Abstractpub_date
2010-03-05 00:00:00pages
968-72issue
5eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00063-3journal_volume
584pub_type
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