Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles.

Abstract:

:The fibroblast growth factor receptor substrate (FRS)-2 protein family comprises FRS2alpha, a well-known central mediator for fibroblast growth factor signaling, and FRS2beta, whose endogenous expression pattern and function are not yet defined. Immunohistochemical analysis revealed that expression of FRS2beta was restricted to neural tissues and it colocalized with Tuj1, a neuronal marker. There are two distinct patterns of FRS2beta expression in neural cells: punctate and cup/ring-shaped; moreover, some particles colocalized with lysosomes. Stimulation with brain-derived neurotrophic factor (BDNF) enhanced FRS2beta phosphorylation and the cup/ring-shaped pattern. These results suggest a probable role of FRS2beta in the intracellular degradation systems of neural cells, which involves lysosomes.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Minegishi Y,Iwanari H,Mochizuki Y,Horii T,Hoshino T,Kodama T,Hamakubo T,Gotoh N

doi

10.1016/j.febslet.2009.01.042

subject

Has Abstract

pub_date

2009-02-18 00:00:00

pages

807-14

issue

4

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(09)00076-3

journal_volume

583

pub_type

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