Abstract:
:A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rosengren E,Aman P,Thelin S,Hansson C,Ahlfors S,Björk P,Jacobsson L,Rorsman Hdoi
10.1016/s0014-5793(97)01261-1subject
Has Abstractpub_date
1997-11-03 00:00:00pages
85-8issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(97)01261-1journal_volume
417pub_type
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