Abstract:
:A number of human diseases can be linked to aberrations in protein folding which cause an imbalance in protein homeostasis. Molecular chaperones, including heat shock proteins, act to assist protein folding, stability and activity in the cell. Attention has begun to focus on modulating the expression and/or activity of this group of proteins for the treatment of a wide variety of human diseases. This review will describe the progress made to date in developing pharmacological modulators of the heat shock response, including both agents which affect the entire heat shock response and those that specifically target the HSP70 and HSP90 chaperone families.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Powers MV,Workman Pdoi
10.1016/j.febslet.2007.05.040subject
Has Abstractpub_date
2007-07-31 00:00:00pages
3758-69issue
19eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00568-6journal_volume
581pub_type
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