Abstract:
:The malaria parasite harbours an indispensable plastid known as the 'apicoplast'. The apicoplast's exact role remains uncertain, but it houses components involved in fatty acid, isoprenoid and haem biosyntheses. These pathways offer opportunities to develop anti-malarials. In the absence of photosynthesis, how apicoplast anabolism is fuelled is unclear. Here we investigated plant-like transporters of the apicoplast and measured their substrate preferences using a novel cell-free assay system to explore the carbon and energy sources of the apicoplast. The transporters exchange triose phosphate and phosphoenolpyruvate for inorganic phosphate, demonstrating that the apicoplast taps into host-derived glucose to fuel its metabolism.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lim L,Linka M,Mullin KA,Weber AP,McFadden GIdoi
10.1016/j.febslet.2009.11.097subject
Has Abstractpub_date
2010-02-05 00:00:00pages
549-54issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(09)01040-0journal_volume
584pub_type
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