Abstract:
:Parathyroid hormone (PTH) binds to its receptor (PTH 1 receptor, PTH1R) and activates multiple pathways. The PTH1R, a class b GPCR, contains consensus calmodulin-binding motifs. The PTH1R cytoplasmic tail interacts with calmodulin in a calcium-dependent manner via the basic 1-5-8-14 motif. Calcium-dependent calmodulin interactions with the cytoplasmic tails of receptors for PTH 2, vasoactive intestinal peptide, pituitary adenylate cyclase activating peptide, corticotropin releasing hormone, calcitonin, and the glucagon-like peptides 1 and 2 are demonstrated. The cytoplasmic tails of the secretin receptor and the growth hormone releasing hormone receptor either interact poorly or not at all with calmodulin, respectively. Fluphenazine, a calmodulin antagonist, enhances PTH-mediated accumulation of total inositol phosphates, suggesting that calmodulin regulates signaling via phospholipase C.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mahon MJ,Shimada Mdoi
10.1016/j.febslet.2004.12.056keywords:
subject
Has Abstractpub_date
2005-01-31 00:00:00pages
803-7issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00011-6journal_volume
579pub_type
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