Abstract:
:We analysed the effects of high cholesterol (HC) intake and reduced apolipoprotein E (apoE) activity on tau phosphorylation and on the activities of the major tau kinases and phosphatases in brains from wild-type and apoE-knockout (apoEKO) mice. We show that HC diet potently induced intraneuronal accumulation of hyperphosphorylated tau in apoEKO mice, as well as upregulation of several tau kinases, without affecting tau phosphatases. Our results suggest an interaction between dietary and genetic factors in the development of tauopathies, which can be relevant in humans, where the apoE4 isoform could have a lack of function as compared to other isoforms.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rahman A,Akterin S,Flores-Morales A,Crisby M,Kivipelto M,Schultzberg M,Cedazo-Mínguez Adoi
10.1016/j.febslet.2005.10.024keywords:
subject
Has Abstractpub_date
2005-11-21 00:00:00pages
6411-6issue
28eissn
0014-5793issn
1873-3468pii
S0014-5793(05)01284-6journal_volume
579pub_type
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