High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice.

Abstract:

:We analysed the effects of high cholesterol (HC) intake and reduced apolipoprotein E (apoE) activity on tau phosphorylation and on the activities of the major tau kinases and phosphatases in brains from wild-type and apoE-knockout (apoEKO) mice. We show that HC diet potently induced intraneuronal accumulation of hyperphosphorylated tau in apoEKO mice, as well as upregulation of several tau kinases, without affecting tau phosphatases. Our results suggest an interaction between dietary and genetic factors in the development of tauopathies, which can be relevant in humans, where the apoE4 isoform could have a lack of function as compared to other isoforms.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Rahman A,Akterin S,Flores-Morales A,Crisby M,Kivipelto M,Schultzberg M,Cedazo-Mínguez A

doi

10.1016/j.febslet.2005.10.024

keywords:

subject

Has Abstract

pub_date

2005-11-21 00:00:00

pages

6411-6

issue

28

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(05)01284-6

journal_volume

579

pub_type

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