Abstract:
:The aim of the present research was to analyze the pathways for phosphatidic acid metabolism in purified nuclei from liver. Lipid phosphate phosphatase, diacylglycerol lipase, monoacylglycerol lipase and PA-phospholipase type A activities were detected. The presence of lysophosphatidic acid significantly reduced DAG production while sphingosine 1-phoshate and ceramide 1-phosphate reduced MAG formation from PA. Using different enzymatic modulators (detergents and ions) an increase in the PA metabolism by phospholipase type A was observed. Our findings evidence an active PA metabolism in purified liver nuclei which generates important lipid second messengers, and which could thus be involved in nuclear processes such as gene transcription.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gaveglio VL,Pasquaré SJ,Giusto NMdoi
10.1016/j.febslet.2013.01.074subject
Has Abstractpub_date
2013-04-02 00:00:00pages
950-6issue
7eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00157-9journal_volume
587pub_type
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