Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG.

abstract：:The trk family of tyrosine protein kinase genes serves crucial roles for the development of the nervous system and the survival of neurons. The members of this gene family, trk, trkB and trkC, bind a distinct neurotrophin of the nerve growth factor (NGF) gene family, and trigger the intracellular signals which elicit ...

journal_title：FEBS letters

authors： Okazawa H,Kamei M,Kanazawa I

更新日期：1993-08-23 00:00:00

abstract：:Culturing human fibroblasts in a three-dimensional collagen matrix leads to a reduction of collagen I by more than 90%, both on the level of mRNA steady-state as well as protein. In order to differentiate changes in de novo transcription and posttranscriptional control, nuclear run on assays and pulse/chase experiment...

journal_title：FEBS letters

authors： Eckes B,Mauch C,Hüppe G,Krieg T

更新日期：1993-03-01 00:00:00

abstract：:LIM-homeodomain (LIM-HD) proteins are evolutionary conserved developmental transcription factors. LIM-HD Lmx1a and Lmx1b orchestrate complex temporal and spatial gene expression of the dopaminergic pathway, and evidence shows they are also involved in adult neuronal homeostasis. In this review, the multiple roles play...

journal_title：FEBS letters

authors： Doucet-Beaupré H,Ang SL,Lévesque M

更新日期：2015-12-21 00:00:00

abstract：:Human serum albumin (HSA) contains a single tryptophan residue at position 214. The emission properties of tryptophan 214 from recombinant albumins, namely, normal HSA, FDH-HSA and a methionine 218 HSA were examined. In all cases, the excited state lifetimes were best described by a two component model consisting main...

journal_title：FEBS letters

authors： Helms MK,Petersen CE,Bhagavan NV,Jameson DM

更新日期：1997-05-12 00:00:00

abstract：:Cav3.2 T-type Ca(2+) channel is required for the activation of calcineurin/NFAT signaling in cardiac hypertrophy. We aimed to investigate how Cav3.2 and calcineurin interact. We found that Ca(2+) and calmodulin modulate the Cav3.2/calcineurin interaction. Calcineurin binding to Cav3.2 decreases the enzyme's phosphatas...

journal_title：FEBS letters

authors： Huang CH,Chen YC,Chen CC

更新日期：2013-06-19 00:00:00

abstract：:Prostaglandin F2alpha, platelet-derived growth factor (PDGF) and calcium ionophore A23187 stimulated the rapid (within 25 s) generation of polyunsaturated 1,2-diacylglycerol (DAG) species, in particular 18:0/20:3n-9, 18:0/20:4n-6 and 18:0/20:5n-3, in Swiss 3T3 fibroblasts. This was followed by a second sustained phase...

journal_title：FEBS letters

authors： Pettitt TR,Wakelam MJ

更新日期：1998-05-15 00:00:00

abstract：:Messenger RNA from intact rat pancreatic islets, or from transformed hamster beta (HIT) cells, hybridized with the cDNA probe for type I (but not type II) phospholipase A2. The levels of phospholipase A2 mRNA increased in islets from fasted rats; they decreased in islets cultured in a high glucose concentration (contr...

journal_title：FEBS letters

authors： Metz S,Holmes D,Robertson RP,Leitner W,Draznin B

更新日期：1991-12-16 00:00:00

abstract：:Glycosaminoglycans (GAGs) are complexed with plasma proteins and proteolysis of plasma reduced the protein-GAG ratio about 140-fold. After dialysis, analysis by gradient PAGE revealed heparinase-1-sensitive GAGs, thus suggesting that heparin could be among the plasma GAGs. However, after dialysis most of the plasma GA...

journal_title：FEBS letters

authors： Chevanne M,Caldini R,Manao G,Ruggiero M,Vannucchi S

更新日期：1999-12-10 00:00:00

abstract：:Rat soleus muscle strips cultured for 24 h in medium 199 were well preserved in terms of electron microscopy; ATP and creatine phosphate concentrations; rates of glucose utilization, glycogen and protein synthesis, and effects of insulin thereon. Culture led to modest changes in fluid spaces and intracellular (K+); in...

journal_title：FEBS letters

authors： Stace PB,Marchington DR,Kerbey AL,Randle PJ

更新日期：1990-10-29 00:00:00

abstract：:Recombinant cell lines expressing D2 and D3 dopamine receptor isoforms have been used to study coupling of these receptors to G-proteins from the effects of GTP to reduce agonist binding affinities in agonist/[3H]spiperone competition experiments. D2(short) expressed in Ltk- cells, D2(long) expressed in Ltk- or CHO ce...

journal_title：FEBS letters

authors： Castro SW,Strange PG

更新日期：1993-01-11 00:00:00

abstract：:The aim of this investigation was to study the effect of intramitochondrial acyl-CoA on the respiration of rabbit heart mitochondria over the whole range of stationary respiratory rates between States 4 and 3. The creatine phosphokinase system was used for stabilization of extramitochondrial adenine nucleotide concent...

journal_title：FEBS letters

authors： Borutaite V,Mildaziene V,Ivanoviene L,Kholodenko B,Toleikis A,Praskevicius A

更新日期：1989-01-30 00:00:00

abstract：:Present analysis procedures for NMR structure determination of macromolecules presuppose fixed internuclear distances. Improvement of the precision of the requisite NOE information has stimulated the use of more quantitative distance constraints thus necessitating examination as to whether the assumption of a rigid mo...

journal_title：FEBS letters

authors： LeMaster DM,Kay LE,Brünger AT,Prestegard JH

更新日期：1988-08-15 00:00:00

abstract：:The orientation of the transition dipole moments in the ground state and the M-intermediate of bacteriorhodopsin were determined by time-resolved and steady-state polarized absorption spectroscopy on samples of oriented immobilized purple membranes. The angle between the transition dipole moment and the membrane norma...

journal_title：FEBS letters

authors： Otto H,Heyn MP

更新日期：1991-11-18 00:00:00

abstract：:We screened active compounds from natural marine products able to increase PPARalpha/gamma transcriptional activity. Sargaquinoic acid (SQA) and sargahydroquinoic acid (SHQA) from Sargassum yezoense were identified as novel PPARalpha/gamma dual agonists. The binding affinity of SQA with PPARgamma was higher than that ...

journal_title：FEBS letters

authors： Kim SN,Choi HY,Lee W,Park GM,Shin WS,Kim YK

更新日期：2008-10-15 00:00:00

abstract：:Beta-thymosins sequester G-actin and preserve a pool of monomers of actin which constitute an important prerequisite for cellular function of the microfilament system. To study the influence of paraquat binding to G-actin on the interaction of G-actin with thymosin beta4 we determined the apparent dissociation constan...

journal_title：FEBS letters

authors： Huff T,Cappelletti G,Hannappel E

更新日期：1998-04-03 00:00:00

abstract：:Mature beta-hexosaminidase A has been found associated to the external leaflet of plasma membrane of cultured fibroblasts. The plasma membrane association of beta-hexosaminidase A has been directly determined by cell surface biotinylation followed by affinity chromatography purification of the biotinylated proteins, a...

journal_title：FEBS letters

authors： Mencarelli S,Cavalieri C,Magini A,Tancini B,Basso L,Lemansky P,Hasilik A,Li YT,Chigorno V,Orlacchio A,Emiliani C,Sonnino S

更新日期：2005-10-24 00:00:00

abstract：:Because A2 adenosine receptor activation stimulates adenylate cyclase and cyclic AMP induces 5'-nucleotidase expression in rat mesangial cells, we examined the effect of adenosine and its analogs on 5'-nucleotidase activity in these cells. A2 adenosine receptors were characterized using [3H]5'-N-ethylcarboxamidoadenos...

journal_title：FEBS letters

authors： Stefanovic V,Vlahovic P,Savic V,Ardaillou N,Ardaillou R

更新日期：1993-09-27 00:00:00

abstract：:Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known to act as a lipid phosphatase hydrolyzing phosphatidylinositol (PI)(3,4,5)P(3) to PI(4,5)P(2). Since the PI3-kinase product, PI(3,4,5)P(3), is an important second messenger leading to the metabolic action of insulin, PTEN functions as a potent neg...

journal_title：FEBS letters

authors： Ishihara H,Sasaoka T,Kagawa S,Murakami S,Fukui K,Kawagishi Y,Yamazaki K,Sato A,Iwata M,Urakaze M,Ishiki M,Wada T,Yaguchi S,Tsuneki H,Kimura I,Kobayashi M

更新日期：2003-11-20 00:00:00

abstract：:There are now at least 14 distinct diseases linked to germ line mutations in the 21 genes that encode the connexin (Cx) family of gap junction proteins. This review focuses on the links between germ-line mutations in the gene encoding Cx43 (GJA1) and the human disease termed oculodentodigital dysplasia (ODDD). This di...

journal_title：FEBS letters

authors： Laird DW

更新日期：2014-04-17 00:00:00

abstract：:Dystrophin is the recently discovered defective gene product in Duchenne and Becker muscular dystrophy (DMD and BMD). Dystrophin transcripts have been amplified and identified in diagnostic needle muscle biopsy samples using the polymerase chain reaction (PCR) procedure. Using 5'- and 3'-primers, dystrophin transcript...

journal_title：FEBS letters

authors： Muntoni F,Strong PN

更新日期：1989-07-31 00:00:00

abstract：:A mouse somatostatin (SS) receptor cDNA was cloned from neuroblastoma x glioma (NG108-15) cells. The sequence is almost identical to that of the mouse SSTR2 receptor [(1992) Proc. Natl. Acad. Sci. USA 89, 251)] but lacks about 300 nucleotides between transmembrane domain VII and the C-terminus. This spliced variant of...

journal_title：FEBS letters

authors： Vanetti M,Kouba M,Wang X,Vogt G,Höllt V

更新日期：1992-10-26 00:00:00

abstract：:The receptor structure of Clostridium botulinum neurotoxin type A was analysed by TLC immunostaining. GQ1b was found to be the most potent receptor, and the neurotoxin also bound to GT1b and GD1a, but not to GM3, GM2, GM1, GD3, GD1b and GT1a. Optimum binding of neurotoxin to the ganglioside appeared in 0.01 M phosphat...

journal_title：FEBS letters

authors： Takamizawa K,Iwamori M,Kozaki S,Sakaguchi G,Tanaka R,Takayama H,Nagai Y

更新日期：1986-06-09 00:00:00

abstract：:Arabidopsis thaliana contains three genes with high homology to potato p24 which was described as a member of the Whirly family of nuclear transcriptional activators. Computer-based analysis revealed that all Arabidopsis Whirly (Why) proteins contain targeting sequences for either plastids or mitochondria. The functio...

journal_title：FEBS letters

authors： Krause K,Kilbienski I,Mulisch M,Rödiger A,Schäfer A,Krupinska K

更新日期：2005-07-04 00:00:00

abstract：:Deproteinized globin poly(A) + mRNAs reassociate readily in vitro with soluble RNA-binding proteins of the cytosol; reconstituted messenger ribonucleoprotein complexes are obtained which are very similar to native globin polyribosomal-mRNP as far as bouyant density in Cs2SO4 and the composition of proteins which can b...

journal_title：FEBS letters

authors： Gaedigk R,Oehler S,Köhler K,Setyono B

更新日期：1985-01-07 00:00:00

abstract：:We provide first large scale analysis of the peculiarities of surface areas of 5658 dissimilar (below 50% sequence similarity) proteins with known 3D-structures that bind to proteins, DNA or RNAs. We show here that area of the protein surface is highly correlated with the protein length. The size of the interface surf...

journal_title：FEBS letters

authors： Wu Z,Hu G,Yang J,Peng Z,Uversky VN,Kurgan L

更新日期：2015-09-14 00:00:00

abstract：:In Xenopus prophase-blocked oocytes, it is assumed that progesterone interacts with the plasma membrane to initiate a signalling cascade that ultimately leads to MPF activation. Progesterone regulates negatively the cAMP pathway through an inhibition of adenylate cyclase. However, the mechanisms linking the initial ac...

journal_title：FEBS letters

authors： De Smedt V,Rime H,Jessus C,Ozon R

更新日期：1995-11-20 00:00:00

abstract：:Methylation of cytosine-residues in the sequence CpG affects the expression of many genes and generally correlates with reduced transcription. The ribosomal genes of Xenopus laevis were among the first genes to be studied with respect to their DNA methylation, and a loss of methylation during embryonic development cor...

journal_title：FEBS letters

authors： Labhart P

更新日期：1994-12-19 00:00:00

abstract：:The influence of aniso-osmolarity on the activity of the MAP kinases Erk-1 and Erk-2 was studied in C6 glioma cells. Hypo-osmotic treatment (205 mosmol/l) led to an increased activity of Erk-1 and Erk-2 within 3 min, which became maximal at 10 min and returned to basal level within 120 min. In contrast, Erk activity w...

journal_title：FEBS letters

authors： Sinning R,Schliess F,Kubitz R,Häussinger D

更新日期：1997-01-03 00:00:00

abstract：:Temporary inhibition of the cysteine proteinases papain and cathepsin L was observed with several hairpin loop mutants of recombinant chicken cystatin at enzyme concentrations above nanomolar. Kinetic modelling of inhibition data, gel electrophoresis and amino acid sequencing revealed that reappearance of papain activ...

journal_title：FEBS letters

authors： Machleidt W,Nägler DK,Assfalg-Machleidt I,Stubbs MT,Fritz H,Auerswald EA

更新日期：1995-03-20 00:00:00

abstract：:Induction of a microsomal oleate delta12 (n-6) desaturase which is mainly responsible for an increase in membrane lipid unsaturation at low temperature has been observed in the free-living amoeba Acanthamoeba castellanii. In this study we show that the enzyme can also be regulated by oxygen independently of temperatur...

journal_title：FEBS letters

authors： Thomas K,Rutter A,Suller M,Harwood J,Lloyd D

更新日期：1998-03-20 00:00:00