Abstract:
:Cav3.2 T-type Ca(2+) channel is required for the activation of calcineurin/NFAT signaling in cardiac hypertrophy. We aimed to investigate how Cav3.2 and calcineurin interact. We found that Ca(2+) and calmodulin modulate the Cav3.2/calcineurin interaction. Calcineurin binding to Cav3.2 decreases the enzyme's phosphatase activity and diminishes the channel's current density. Phenylephrine-induced hypertrophy in neonatal cardiac myocytes is reduced by a cell-permeable peptide with the calcineurin binding site sequence. These data suggest that Cav3.2 regulates calcineurin/NFAT pathway through both the Ca(2+) influx and calcineurin binding. Our findings unveiled a reciprocal regulation of Ca(2+) signaling which contributes to our understanding of cardiac hypertrophy.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Huang CH,Chen YC,Chen CCdoi
10.1016/j.febslet.2013.04.040subject
Has Abstractpub_date
2013-06-19 00:00:00pages
1723-30issue
12eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00335-9journal_volume
587pub_type
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