Abstract:
:Membrane incorporation and aggregation of the peptide alamethicin have been investigated as a function of lipid type. Head group and acyl chain regions both contribute to modulate alamethicin incorporation. Specifically, the peptide prefers thin membranes and saturated chains; incorporation is reduced by the presence of cholesterol. Aggregation of the peptide in the bilayer is virtually insensitive to changes in lipid composition. These findings show some analogies to results obtained with intrinsic membrane proteins and cast doubt on the use of global membrane parameters for interpreting lipid-peptide interactions.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Stankowski S,Schwarz Gdoi
10.1016/0014-5793(89)80795-1subject
Has Abstractpub_date
1989-07-03 00:00:00pages
556-60issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(89)80795-1journal_volume
250pub_type
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