Abstract:
:Two genes code for calcitonin gene-related peptides (CGRPs). One expresses by tissue-specific alternate splicing calcitonin and CGRP I mRNAs, the other CGRP II mRNA. Calcitonin is the marker of sporadic or hereditary human medullary thyroid carcinoma (MTC). CGRP II expression is not well established in normal or tumoral thyroid. After amplification by polymerase chain reaction, CGRP I and II mRNAs were detected in six cases of MTC associated with other endocrine neoplasia (MEN IIa) and in two cases of isolated MTC. CGRP I was detected in all non-C cell tumoral thyroids (6 samples), CGRP II was barely detectable in three out of six cases. CGRP II could be a specific tumoral marker of MTC.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lasmoles F,Minvielle S,Cohen R,Guliana JM,Delehaye MC,Segond N,Calmettes C,Milhaud G,Moukhtar MSdoi
10.1016/0014-5793(90)80856-esubject
Has Abstractpub_date
1990-12-17 00:00:00pages
243-6issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(90)80856-Ejournal_volume
277pub_type
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