Abstract:
:Studies of the inhibition of elastases at a molecular level have resulted in the identification of protected dipeptides which are reversible and highly specific inhibitors of human leucocyte elastase (HLE). These have been further developed by increasing their hydrophilicity and potency to give a new family of elastase inhibitors, typically N alpha-(1-adamantanesulphonyl)-N epsilon-(4-carboxybenzoyl)-L-lysyl-L-alanyl-L-valinal. These compounds are active in pharmacological models designed to detect compounds of potential therapeutic value in the treatment of emphysema.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hassall CH,Johnson WH,Kennedy AJ,Roberts NAdoi
10.1016/0014-5793(85)80776-6subject
Has Abstractpub_date
1985-04-22 00:00:00pages
201-5issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(85)80776-6journal_volume
183pub_type
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