Abstract:
:PPP2R2C encodes a gamma isoform of the subunit B55 subfamily, which is a regulatory subunit of Protein phosphatase type 2A (PP2A). Our study shows that PPP2R2C is downregulated in glioma cells and human brain cancer patient samples. Overexpression of PPP2R2C inhibited cancer cell proliferation both in vitro and in vivo through the suppression of the activity of S6K in the mTOR pathway. Moreover, exogenous expression of PPP2R2C promoted the formation of a complex with the PP2A-C subunit to further enhance the binding of PP2A-C with S6K. Our results suggest that PPP2R2C is a potential tumor suppressor gene in human brain cancers. This study will provide novel insight into the development of therapeutic strategies in the treatment of human brain tumors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fan YL,Chen L,Wang J,Yao Q,Wan JQdoi
10.1016/j.febslet.2013.09.029subject
Has Abstractpub_date
2013-12-11 00:00:00pages
3892-7issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00724-2journal_volume
587pub_type
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