Abstract:
:The metastasis suppressor KAI1/CD82 has been implicated in various cellular processes; however, its function in development is not fully understood. Here, we generated and characterized mutants of Tsp66E and Tsp74F, which are Drosophila homologues of KAI1/CD82 and Tspan11, respectively. These mutants exhibited egg elongation defects along with disturbed integrin localization and actin polarity. Moreover, the defects were enhanced by mutation of inflated, an αPS2 integrin gene. Mutant ovaries had elevated αPS2 integrin levels and reduced endocytic trafficking. These results suggest that Drosophila KAI1/CD82 affects the polarized localization and the level of integrin, which may contribute to epithelial cell polarity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Han SY,Lee M,Hong YK,Hwang S,Choi G,Suh YS,Park SH,Lee S,Lee SH,Chung J,Baek SH,Cho KSdoi
10.1016/j.febslet.2012.09.044subject
Has Abstractpub_date
2012-11-16 00:00:00pages
4031-7issue
22eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00768-5journal_volume
586pub_type
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