Activation of the WT1 tumor suppressor gene promoter by Pea3.

abstract：:5(S)-Hydroxyicosatetraenoate stimulates human polymorphonuclear neutrophils (PMNs) to raise their cytosolic calcium. It also potentiates the cells' degranulation responses to platelet-activating factor and diacylglycerols. We synthesized 5(R)-hydroxyicosatetraenoate and found it to be 20-100-fold weaker than the natur...

journal_title：FEBS letters

authors： Rossi AG,Thomas MJ,O'Flaherty JT

更新日期：1988-11-21 00:00:00

abstract：:We have investigated the effect of botulinum neurotoxin (BoNT) C1 light chain (LC) on insulin exocytosis from the clonal beta-cell line HIT-T15. In streptolysin-O permeabilized cells, the beta-cell impermeant BoNT C1 cleaved mainly syntaxin 1 and inhibited Ca2+ as well as GTPgammaS induced exocytosis. To study the eff...

journal_title：FEBS letters

authors： Land J,Zhang H,Vaidyanathan VV,Sadoul K,Niemann H,Wollheim CB

更新日期：1997-12-08 00:00:00

abstract：:Rhodamine 6G (3 microM) effectively inhibited delta pH-driven ATP synthesis in Methanobacterium thermoautotrophicum while delta pNa-driven ATP synthesis was not affected by it. Rhodamine 6G inhibited Mg(2+)-stimulated ATPase activity of membrane vesicles prepared from these cells but the ATPase catalytic sector detach...

journal_title：FEBS letters

authors： Smigán P,Majerník A,Greksák M

更新日期：1994-06-27 00:00:00

abstract：:The cDNA coding for a novel member of the cysteine-rich protein family was isolated from a rat brain cDNA library. It encodes a protein, denoted cysteine-rich protein 2 (CRP2), of 208 amino acid residues containing two tandem repeats of an unusual LIM/double zinc-finger-like motif. The ubiquitous tissue distribution a...

journal_title：FEBS letters

authors： Okano I,Yamamoto T,Kaji A,Kimura T,Mizuno K,Nakamura T

更新日期：1993-10-25 00:00:00

abstract：:A series of 9-beta-D-xylofuranosyladenine (xyloA or xyloadenosine) substituted analogs of 2-5A core trimer and tetramer were examined for their ability to be degraded by the 2',5'-phosphodiesterase activity of cytoplasmic extracts of mouse L cells. Two distinct groups of xyloA-substituted analogs could be readily disc...

journal_title：FEBS letters

authors： Torrence PF,Alster D,Huss S,Gosselin G,Imbach JL

更新日期：1987-02-23 00:00:00

abstract：:Acaryochloris marina is a prochlorophyte-like cyanobacterium containing both phycobilins and chlorophyll d as light harvesting pigments. We show that the chlorophyll d light harvesting system, composed of Pcb proteins, functionally associates with the photosystem II (PSII) reaction center (RC) core to form a giant sup...

journal_title：FEBS letters

authors： Chen M,Bibby TS,Nield J,Larkum AW,Barber J

更新日期：2005-02-14 00:00:00

abstract：:Connivance of cellular factors during virus-host cell membrane fusion is poorly understood. We have recently shown that cellular villin plays an important role during membrane fusion of reconstituted Sendai virosomes with hepatocytes. Here, we employed villin-null Chinese Hamster Ovary (CHO) cells, where villin expres...

journal_title：FEBS letters

authors： Chandra S,Kumar M,Sharma NR,Sarkar DP

更新日期：2019-08-01 00:00:00

abstract：:The effect of the uremic solute indoxyl sulfate (IS) on scavenging superoxide anion radicals (O(2)(*-)) generated from both the xanthine/xanthine oxidase (X/XO) system and activated neutrophils was investigated by electron paramagnetic resonance spectroscopy, combined with 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrr...

journal_title：FEBS letters

authors： Miyamoto Y,Iwao Y,Tasaki Y,Sato K,Ishima Y,Watanabe H,Kadowaki D,Maruyama T,Otagiri M

更新日期：2010-07-02 00:00:00

abstract：:Despite their differential cell tropisms, HIV-1 and HCV dramatically influence disease progression in coinfected patients. Macrophages are important target cells of HIV-1. We hypothesized that secreted HCV core protein might modulate HIV-1 replication. We demonstrate that HCV core significantly enhances HIV-1 replicat...

journal_title：FEBS letters

authors： Swaminathan G,Pascual D,Rival G,Perales-Linares R,Martin-Garcia J,Navas-Martin S

更新日期：2014-09-17 00:00:00

abstract：:A novel peptidyl-prolyl cis/trans isomerase was isolated from Escherichia coli cell extract and characterized partially. Determination of the molecular mass by electrospray mass spectrometry indicated a protein of 10102 +/- 2 Da, smaller than cyclophilins or FK 506 binding proteins currently known. The specificity con...

journal_title：FEBS letters

authors： Rahfeld JU,Schierhorn A,Mann K,Fischer G

更新日期：1994-04-18 00:00:00

abstract：:A role for the cytokines produced by tissue-infiltrated inflammatory cells (mainly T-lymphocytes and mast cells) in the pathophysiology of fibrosis has been suggested by several groups. Among the products of these cells, interleukin-4 (IL-4) might be one of the factors involved in the initiation of the fibrotic proces...

journal_title：FEBS letters

authors： Gillery P,Fertin C,Nicolas JF,Chastang F,Kalis B,Banchereau J,Maquart FX

更新日期：1992-05-18 00:00:00

abstract：:Micromolar concentrations of arachidonic acid cause in Ca2+ loaded heart mitochondria matrix swelling and Ca2+ release. These effects appear to be unrelated to the classical membrane permeability transition (MPT), as they are CsA insensitive, membrane potential independent and can also be activated by Sr2+. Atractylos...

journal_title：FEBS letters

authors： Di Paola M,Zaccagnino P,Oliveros-Celis C,Lorusso M

更新日期：2006-02-06 00:00:00

abstract：:Human nuclear cyclophilin 33 (hCyP33) was the first protein which was found to contain an RNA-binding motif and a PPIase domain. It was not known what cellular and physiological roles are played by the RNA-binding activity as well as the PPIase activity of hCyP33. In this paper, we investigated the binding specificity...

journal_title：FEBS letters

authors： Wang Y,Han R,Zhang W,Yuan Y,Zhang X,Long Y,Mi H

更新日期：2008-03-05 00:00:00

abstract：:Polymerising proteins of the actin family are nearly ubiquitous. Crenactins, restricted to Crenarchaea, are more closely related to actin than bacterial MreB. Crenactins occur in gene clusters hinting at an unknown, but conserved function. We solved the crystal structure of crenactin at 3.2 Å resolution. The protein c...

journal_title：FEBS letters

authors： Izoré T,Duman R,Kureisaite-Ciziene D,Löwe J

更新日期：2014-03-03 00:00:00

abstract：:To investigate the cis-acting DNA elements that are involved in the regulation of class I major histocompatibility complex genes by interferon, several promoter fragments of the H-2Kk gene were linked to the reporter chloramphenicol acetyl transferase (CAT) gene, and the CAT expression was analyzed in stable transfect...

journal_title：FEBS letters

authors： Pascucci A,Pannuti A,La Mantia G,Lania L

更新日期：1988-01-04 00:00:00

abstract：:Advanced glycation end products (AGE) are known to serve as ligands for the scavenger receptors such as SR-A, CD36 and SR-BI. In the current study, we examined whether AGE is recognized by lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). Cellular binding experiments revealed that AGE-bovine serum album...

journal_title：FEBS letters

authors： Jono T,Miyazaki A,Nagai R,Sawamura T,Kitamura T,Horiuchi S

更新日期：2002-01-30 00:00:00

abstract：:Type II collagen is the major protein of cartilage and is synthesized as a procollagen in two forms (IIA and IIB), generated by differential splicing of the gene primary transcript. Previous studies have indicated that only type IIB is expressed in differentiated chondrocytes. Here, we examined the effects of bone mor...

journal_title：FEBS letters

authors： Valcourt U,Gouttenoire J,Aubert-Foucher E,Herbage D,Mallein-Gerin F

更新日期：2003-06-19 00:00:00

abstract：:Platinum electrodes can be coated with cytochrome b5-phospholipid monolayers by the Langmuir-Blodgett technique. Cyclic voltammetry of a series of dyes shows that the coated electrodes become selective for certain electroactive species. The electron transfer reactions of negatively charged species are inhibited at the...

journal_title：FEBS letters

authors： Zaba BN,Wilkinson MC,Taylor DM,Lewis TJ,Laidman DL

更新日期：1987-03-09 00:00:00

abstract：:Complex I (NADH:ubiquinone oxidoreductase) is the first and largest protein complex of the oxidative phosphorylation. Crystal structures have elucidated the positions of most subunits of bacterial evolutionary origin in the complex, but the positions of the eukaryotic subunits are unknown. Based on the analysis of seq...

journal_title：FEBS letters

authors： Szklarczyk R,Wanschers BF,Nabuurs SB,Nouws J,Nijtmans LG,Huynen MA

更新日期：2011-03-09 00:00:00

abstract：:We have previously described a partial cDNA sequence encoding a RhoGAP protein, GAP25 that is homologous to the recently reported ArhGAP9 and ArhGAP12. We now describe a related new member ArhGAP15 that shares a number of domain similarities, including a pleckstrin homology (PH) domain, a RhoGAP domain and a novel mot...

journal_title：FEBS letters

authors： Seoh ML,Ng CH,Yong J,Lim L,Leung T

更新日期：2003-03-27 00:00:00

abstract：:The cofactor of several flavoenzymes is autocatalytically bound to the polypeptide via a histidyl(N3)-(8alpha)-FAD linkage which makes the generation of apoenzyme difficult. We introduced an alternative covalent protein-FAD bond at the active site of 6-hydroxy-D-nicotine oxidase (6HDNO) by replacing the FAD-binding hi...

journal_title：FEBS letters

authors： Stoltz M,Henninger HP,Brandsch R

更新日期：1996-05-20 00:00:00

abstract：:We present evidence that the potent chloride channel blocker NPPB has protonophoric activity in the mitochondria and across the plasma membrane of phagocytic cells. The resting O2 consumption of murine peritoneal macrophages was stimulated up to 2.5-fold in the presence of NPPB, with a K0.5 of 15 microM. The stimulato...

journal_title：FEBS letters

authors： Lukacs GL,Nanda A,Rotstein OD,Grinstein S

更新日期：1991-08-19 00:00:00

abstract：:Polyglutamine tract-binding protein 1 (PQBP1) is an intrinsically disordered protein abundantly expressed in the brain. Mutations in the PQBP1 gene are causative for X-linked mental retardation disorders. Here, we investigated the structure of the C-terminal segment within the context of full-length PQBP1. We produced...

journal_title：FEBS letters

authors： Nabeshima Y,Mizuguchi M,Kajiyama A,Okazawa H

更新日期：2014-12-20 00:00:00

abstract：:We explored the interactive effects of endothelial nitric oxide synthase (eNOS) genotypes and cigarette smoking on protein levels and enzyme activity in 33 postpartum placentas. Whilst the eNOS protein levels were lower in the rare allele (0.48+/-0.11, n=9 vs. 1. 05+/-0.10, n=24, P<0.01), the eNOS enzyme activity was ...

journal_title：FEBS letters

authors： Wang XL,Sim AS,Wang MX,Murrell GA,Trudinger B,Wang J

更新日期：2000-04-07 00:00:00

abstract：:Structural differences between platelet and endothelial cell thrombospondin (TBSP) were found in two protease-resistant domains (70 and 18 kDa). The 70 kDa fragment is involved in the binding of TBSP to fibrinogen and the 18 kDa fragment in the attachment to various cultured cells. Despite these structural differences...

journal_title：FEBS letters

authors： Clezardin P,Bourdillon MC,Hunter NR,McGregor JL

更新日期：1988-02-15 00:00:00

abstract：:The tuf gene of eubacteria, encoding the EF-tu elongation factor, was duplicated early in the evolution of the taxon. Phylogenetic and genomic location analysis of 20 complete eubacterial genomes suggests that this ancient duplication has been differentially lost and maintained in eubacteria. ...

journal_title：FEBS letters

authors： Lathe WC 3rd,Bork P

更新日期：2001-08-03 00:00:00

abstract：:Aspergillus nidulans catalase B (CatB) was purified to homogeneity and characterized as a hydroperoxidase which resembles typical catalases in some physicochemical characteristics: (1) it has an apparent molecular weight of 360000 and is composed of four glycosylated subunits, (2) it has hydrophobic properties as reve...

journal_title：FEBS letters

authors： Calera JA,Sánchez-Weatherby J,López-Medrano R,Leal F

更新日期：2000-06-16 00:00:00

abstract：:Leucine-rich repeats (LRRs) are 22-28 amino acid-long sequence motifs found in a family of cytoplasmic, membrane and extracellular proteins. There is evidence that LRRs function in signal transduction, cellular adhesion and protein-protein interactions. Here we report unusual properties of a synthetic LRR peptide deri...

journal_title：FEBS letters

authors： Gay NJ,Packman LC,Weldon MA,Barna JC

更新日期：1991-10-07 00:00:00

abstract：:The C-terminal regions of Kv1 K+ channels show little conservation between isoforms except for the last four C-terminal residues, (E/L)TDV, which are well conserved from Drosophila to man. Deletions of the 4, 16, and 57 C-terminal residues of the human Kv1.5 channel did not affect whole cell current amplitude, midpoin...

journal_title：FEBS letters

authors： Uebele VN,Yeola SW,Snyders DJ,Tamkun MM

更新日期：1994-02-28 00:00:00

abstract：:Determination of the protonation state of enzymes is a challenging problem in computational biophysics largely due to the vast number of possible protonic configurations. The protonation state dynamics of respiratory complex I was investigated via Monte Carlo and asynchronous dynamics simulations and a novel eigenvect...

journal_title：FEBS letters

authors： Couch V,Stuchebrukhov A

更新日期：2012-03-09 00:00:00