Abstract:
:Despite their differential cell tropisms, HIV-1 and HCV dramatically influence disease progression in coinfected patients. Macrophages are important target cells of HIV-1. We hypothesized that secreted HCV core protein might modulate HIV-1 replication. We demonstrate that HCV core significantly enhances HIV-1 replication in human macrophages by upregulating TNF-α and IL-6 via TLR2-, JNK-, and MEK1/2-dependent pathways. Furthermore, we show that TNF-α and IL-6 secreted from HCV core-treated macrophages reactivates monocytic U1 cells latently infected with HIV-1. Our studies reveal a previously unrecognized role of HCV core by enhancing HIV-1 infection in macrophages.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Swaminathan G,Pascual D,Rival G,Perales-Linares R,Martin-Garcia J,Navas-Martin Sdoi
10.1016/j.febslet.2014.08.009subject
Has Abstractpub_date
2014-09-17 00:00:00pages
3501-10issue
18eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00610-3journal_volume
588pub_type
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