Abstract:
:The addition of hepatocyte growth factor (HGF) to rat hepatocytes in primary culture resulted in the formation of inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and 1,2-diacylglycerol (DG) by a phosphoinositide-specific phospholipase C (PI-PLC). DG showed a biphasic increase; the first phase, corresponding with the peak of Ins(1,4,5)P3 and a second larger and prolonged phase. The HGF stimulates the phosphatidylcholine (PC)-derived prolonged DG formation by a phospholipase C pathway (PC-PLC) but not by a phospholipase D pathway. HGF also was found to elicit [Ca2+] oscillations which may be associated with the prolonged DG production from PC via the PC-PLC phospholipase C pathway.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Osada S,Nakashima S,Saji S,Nakamura T,Nozawa Ydoi
10.1016/0014-5793(92)80554-tkeywords:
subject
Has Abstractpub_date
1992-02-10 00:00:00pages
271-4issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(92)80554-Tjournal_volume
297pub_type
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