Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE).

abstract：:Methyllycaconitine (MLA) is a competitive antagonist of nicotinic acetylcholine receptors, with a remarkable preference for neuronal [125I]alpha Bgt binding sites. We have begun to investigate the structural basis of its potency and subtype selectivity. MLA is a substituted norditerpenoid alkaloid linked to a 2-(methy...

journal_title：FEBS letters

authors： Hardick DJ,Cooper G,Scott-Ward T,Blagbrough IS,Potter BV,Wonnacott S

更新日期：1995-05-22 00:00:00

abstract：:We present here a combined GC-MS and LC-MS metabolic profiling approach to unraveling the pathological outcomes of aristolochic acid (AA)-induced nephrotoxicity. Urine samples were analyzed by GC-MS and LC-MS in combination with pattern recognition techniques, e.g. principal component analysis (PCA), orthogonal projec...

journal_title：FEBS letters

authors： Ni Y,Su M,Qiu Y,Chen M,Liu Y,Zhao A,Jia W

更新日期：2007-02-20 00:00:00

abstract：:The ATP synthase capacity of rat heart myocytes can be measured in sonicates of cultured cardiomyocytes. In these cells, transitions in ATP synthase capacity occur on changing to the anoxic or uncoupled state (drop in ATP synthase capacity of over 40%) or on electrically stimulating the cells to contract (rise of 70%)...

journal_title：FEBS letters

authors： Das AM,Harris DA

更新日期：1989-10-09 00:00:00

abstract：:The hepatitis B viral X protein (HBx) is a multifunctional protein that plays a role in the activation of the NF-kappaB signaling pathway. In this study, we demonstrate that HBx up-regulates expression of TANK-binding kinase-1 (TBK1) at the transcriptional level. Increased levels of TBK1 protein then induce the phosph...

journal_title：FEBS letters

authors： Kim HR,Lee SH,Jung G

更新日期：2010-02-05 00:00:00

abstract：:Data obtained from peptide mapping of the active and inactive forms of human renin show that there are extensive regions of common sequence in the two forms of the enzyme, and are consistent with the hypothesis that inactive renin is a renin zymogen. ...

journal_title：FEBS letters

authors： McIntyre GD,Chaudhuri S,Coggins JR

更新日期：1984-10-01 00:00:00

abstract：:The early response to bacterial inoculation has been investigated and two Arabidopsis genes, ap3.3a and ap4.3a have been characterized. The AP3.3A protein showed high identity to centrin, a ubiquitous cytoskeletal protein first identified in unicellular green alga. Amino-acid sequence analyses of the AP4.3A protein in...

journal_title：FEBS letters

authors： Cordeiro MC,Piqueras R,de Oliveira DE,Castresana C

更新日期：1998-09-04 00:00:00

abstract：:A PCR-based subtractive cloning procedure was used to identify genes expressed at higher levels in the pancreatic beta cell line betaTC1, as compared to the pancreatic alpha cell line alphaTC1. One of the clones isolated by this procedure corresponded to the regulatory subunit (RIalpha) of protein kinase A (PKA). Usin...

journal_title：FEBS letters

authors： Arava Y,Adamsky K,Belleli A,Shaltiel S,Walker MD

更新日期：1998-03-20 00:00:00

abstract：:Analyzing the primary structure we predicted that calponin may interact with phospholipids. In order to check this suggestion we investigated the interaction of calponin with phospholipids by ultracentrifugation, light scattering, vesicles leakage and differential scanning calorimetry. In agreement with our prediction...

journal_title：FEBS letters

authors： Bogatcheva NV,Gusev NB

更新日期：1995-09-04 00:00:00

abstract：:The role of necrotic and apoptotic pathways in cytolysis mediated by LAK cells was studied. The contribution of necrotic and apoptotic processes to cytolysis depends both on the LAK cells' phenotype and the type of target cells. CD16+/CD8+/CD3- LAK cells induced necrosis of K562 and L929 target cells. The cell death i...

journal_title：FEBS letters

authors： Sashchenko LP,Kabanova OD,Blishchenko LYu,Lukjianova TI,Satpaev DK,Chertov OYu,Gnuchev NV

更新日期：1993-12-06 00:00:00

abstract：:Although transthyretin (TTR) is expressed in pancreatic alpha (glucagon) cells in the islets of Langerhans, the function of TTR in pancreatic alpha cells remains unknown. In this study, by using TTR knockout (TTR KO) mice, we determined the novel role of TTR in glucose homeostasis. We demonstrated that TTR KO mice evi...

journal_title：FEBS letters

authors： Su Y,Jono H,Misumi Y,Senokuchi T,Guo J,Ueda M,Shinriki S,Tasaki M,Shono M,Obayashi K,Yamagata K,Araki E,Ando Y

更新日期：2012-11-30 00:00:00

abstract：:Human nuclear cyclophilin 33 (hCyP33) was the first protein which was found to contain an RNA-binding motif and a PPIase domain. It was not known what cellular and physiological roles are played by the RNA-binding activity as well as the PPIase activity of hCyP33. In this paper, we investigated the binding specificity...

journal_title：FEBS letters

authors： Wang Y,Han R,Zhang W,Yuan Y,Zhang X,Long Y,Mi H

更新日期：2008-03-05 00:00:00

abstract：:Recombinant adipogenesis inhibitory factor (AGIF) was purified to homogeneity from the conditioned medium of COS-1 cells transfected with human AGIF cDNA. The amino-terminal sequence analysis of the mature AGIF revealed that AGIF was produced as a precursor consisting of 199 amino acids and processed into a mature for...

journal_title：FEBS letters

authors： Ohsumi J,Miyadai K,Kawashima I,Ishikawa-Ohsumi H,Sakakibara S,Mita-Honjo K,Takiguchi Y

更新日期：1991-08-19 00:00:00

abstract：:We analysed the effects of high cholesterol (HC) intake and reduced apolipoprotein E (apoE) activity on tau phosphorylation and on the activities of the major tau kinases and phosphatases in brains from wild-type and apoE-knockout (apoEKO) mice. We show that HC diet potently induced intraneuronal accumulation of hyper...

journal_title：FEBS letters

authors： Rahman A,Akterin S,Flores-Morales A,Crisby M,Kivipelto M,Schultzberg M,Cedazo-Mínguez A

更新日期：2005-11-21 00:00:00

abstract：:The gene for the extracellular ribonuclease of B. pumilus KMM62 (RNase Bp) has been cloned and sequenced. The structural gene for this enzyme is similar to those of the extracellular ribonucleases of B. intermedius 7P (binase) and B. amyloliquefaciens H2 (barnase), as are the regulatory regions of binase and RNase Bp....

journal_title：FEBS letters

authors： Znamenskaya LV,Gabdrakhmanova LA,Chernokalskaya EB,Leshchinskaya IB,Hartley RW

更新日期：1995-01-02 00:00:00

abstract：:The accumulation of pre-PhoS under conditions of PhoS overproduction has been previously described. It is now demonstrated that during the induction of PhoS, a delay in the completion of polypeptide chain elongation can be detected. This delay is related to the extent of jamming of export sites by pre-PhoS or by other...

journal_title：FEBS letters

authors： Anba J,Lazdunski C,Pages JM

更新日期：1986-02-03 00:00:00

abstract：:A rapid and efficient method for the purification of malate synthase, an enzyme uniquely confined to glyoxysomes, from cotyledons of Brassica napus L. has been developed. The two step purification procedure is based on the consequent utilization of the tendency of malate synthase to form high molecular weight aggregat...

journal_title：FEBS letters

authors： Hoppe A,Theimer RR

更新日期：1995-10-30 00:00:00

abstract：:HIV gp120 is specifically cleaved at a single site in the V3 loop between Arg315 and Ala316 by thrombin. Previous observations by others have indicated that binding to CD4 enhances the rate of V3 loop cleavage, and that this cleavage is a prerequisite for HIV infection. Other observations also suggest that the cleavag...

journal_title：FEBS letters

authors： Johnson ME,Lin Z,Padmanabhan K,Tulinsky A,Kahn M

更新日期：1994-01-03 00:00:00

abstract：:tRNAs play a central role in protein translation, acting as the carrier of amino acids. By cloning microRNAs, we unexpectedly obtained some tRNA fragments generated by tRNA cleavage in the anticodon loop. These tRNA fragments are present in many cell lines and different mouse tissues. In addition, various stress condi...

journal_title：FEBS letters

authors： Fu H,Feng J,Liu Q,Sun F,Tie Y,Zhu J,Xing R,Sun Z,Zheng X

更新日期：2009-01-22 00:00:00

abstract：:Branched-chain 2-oxoacid dehydrogenase complex has been purified to near homogeneity by a simple, rapid procedure. The final product contains endogenous kinase activity capable of phosphorylating and inactivating the complex. Phosphorylation continues after complete inactivation, indicating the possibility of several ...

journal_title：FEBS letters

authors： Lawson R,Cook KG,Yeaman SJ

更新日期：1983-06-27 00:00:00

abstract：:Here we make a brief survey of the present state of antibiotic research and use. We also describe a novel antibiotic that contains a basic peptide covalently bound to a morpholino oligonucleotide. ...

journal_title：FEBS letters

authors： Altman S

更新日期：2014-01-03 00:00:00

abstract：:The transcription factor Pdr1p recognizes Pdr1p/Pdr3p-response element (PDRE) to activate genes involved in multidrug resistance of the budding yeast. To identify novel targets of Pdr1p, we compared transcriptomes among the yeast cells bearing wild, disrupted and gain-of-function alleles of PDR1 using a high-throughpu...

journal_title：FEBS letters

authors： Miura F,Yada T,Nakai K,Sakaki Y,Ito T

更新日期：2001-09-07 00:00:00

abstract：:LipL and Cpr19 are nonheme, mononuclear Fe(II)-dependent, α-ketoglutarate (αKG):UMP oxygenases that catalyze the formation of CO2 , succinate, phosphate, and uridine-5'-aldehyde, the last of which is a biosynthetic precursor for several nucleoside antibiotics that inhibit bacterial translocase I (MraY). To better unde...

journal_title：FEBS letters

authors： Goswami A,Liu X,Cai W,Wyche TP,Bugni TS,Meurillon M,Peyrottes S,Perigaud C,Nonaka K,Rohr J,Van Lanen SG

更新日期：2017-02-01 00:00:00

abstract：:Hexaheme nitrite reductases purified to homogeneity from Escherichia coli K-12 and Wolinella succinogenes were studied by low-temperature EPR spectroscopy. In their isolated states, the two enzymes revealed nearly identical EPR spectra when measured at 12 K. Both high-spin and low-spin ferric heme EPR resonances with ...

journal_title：FEBS letters

authors： Liu MC,Liu MY,Payne WJ,Peck HD Jr,Le Gall J,DerVartanian DV

更新日期：1987-06-29 00:00:00

abstract：:Amyloid precursor protein (APP) gene expression was investigated in primary cultures of neurons, astrocytes, microglial cells and oligodendrocytes. Neurons from various rat brain regions, as well as oligodendrocytes, contained RNA encoding APP695, while astrocytes and microglial cells expressed high levels of RNAs for...

journal_title：FEBS letters

authors： Gaul G,Dutly F,Frei K,Foguet M,Lübbert H

更新日期：1992-08-03 00:00:00

abstract：:A ratio-fluorescence assay was developed for on-line localization and quantification of lipid oxidation in living cells. The assay explores the oxidative sensitivity of C11-BODIPY(581/591). Upon oxidation, the fluorescence of this fluorophore shifts from red to green. The probe incorporates readily into cellular membr...

journal_title：FEBS letters

authors： Pap EH,Drummen GP,Winter VJ,Kooij TW,Rijken P,Wirtz KW,Op den Kamp JA,Hage WJ,Post JA

更新日期：1999-06-25 00:00:00

abstract：:The MAP kinase module (Raf/MAPKKK-MAPKK-MAPK) has been shown to be sequentially activated after mitogenic stimulation. Here we demonstrate, by site directed mutagenesis, that MAPK is able to retrophosphorylate its own activator, MAPKK, on two threonine residues Thr-292 and Thr-386 in vitro, and that these sites are al...

journal_title：FEBS letters

authors： Brunet A,Pagès G,Pouysségur J

更新日期：1994-06-13 00:00:00

abstract：:The isocitrate lyase-encoding gene AgICL1 from the filamentous hemiascomycete Ashbya gossypii was isolated by heterologous complementation of a Saccharomyces cerevisiae icl1d mutant. The open reading frame of 1680 bp encoded a protein of 560 amino acids with a calculated molecular weight of 62584. Disruption of the Ag...

journal_title：FEBS letters

authors： Maeting I,Schmidt G,Sahm H,Revuelta JL,Stierhof YD,Stahmann KP

更新日期：1999-02-05 00:00:00

abstract：:Annexins are multifunctional intracellular proteins with Ca2+- and phospholipid-binding properties. Their structures consist of four conserved repeat domains that form the core and a diverse N-terminal tail, from which their functional differences may arise. We searched for cellular proteins that interact with the N-t...

journal_title：FEBS letters

authors： Lee KH,Na DS,Kim JW

更新日期：1999-01-15 00:00:00

abstract：:Apolipoprotein E (APOE) genotype determines Alzheimer's disease (AD) susceptibility, with the APOE ε4 allele being an established risk factor for late-onset AD. The ApoE lipidation status has been reported to impact amyloid-beta (Aβ) peptide metabolism. The details of how lipidation affects ApoE behavior remain to be ...

journal_title：FEBS letters

authors： Hubin E,Verghese PB,van Nuland N,Broersen K

更新日期：2019-06-01 00:00:00

abstract：:Water-soluble amyloid beta-peptides (sA beta), ending at residue 42, precede amyloid plaques in Down's syndrome (DS). Here we report that sA beta consists of the full-length A beta(1-42) and peptides truncated and modified by cyclization of the N-terminal glutamates, A beta[3(pE)-42] and A beta[11(pE)-42]. The A beta[...

journal_title：FEBS letters

authors： Russo C,Saido TC,DeBusk LM,Tabaton M,Gambetti P,Teller JK

更新日期：1997-06-16 00:00:00