Abstract:
:The hepatitis B viral X protein (HBx) is a multifunctional protein that plays a role in the activation of the NF-kappaB signaling pathway. In this study, we demonstrate that HBx up-regulates expression of TANK-binding kinase-1 (TBK1) at the transcriptional level. Increased levels of TBK1 protein then induce the phosphorylation of NF-kappaB p65 at serine 536. Because TBK1 is up-regulated by HBx as part of its promotion of NF-kappaB activation, it is possible that increased TBK1 levels play a role in the development of hepatocellular carcinoma (HCC). From these data, we suggest that TBK1 may play a role in the HBx-mediated activation of the NF-kappaB signaling pathway and the development of HCCs.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kim HR,Lee SH,Jung Gdoi
10.1016/j.febslet.2009.11.091subject
Has Abstractpub_date
2010-02-05 00:00:00pages
525-30issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(09)01031-Xjournal_volume
584pub_type
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