Abstract:
:Insulin resistant states are associated with an increase in the beta cell mass and also high levels of circulating insulin. Ultimately the beta cells undergo a failure that leads to diabetes. At this stage, a question arises if those persistent high levels of circulating insulin may contribute to beta cell damage. To address this important issue, we submitted beta cells to a prolonged effect of increasing concentrations of insulin. We observed that a prolonged effect of high levels of insulin on the presence of serum (15-24h) in glucose-deprived beta cells induced apoptosis. This apoptotic effect was both dose- and cycloheximide-dependent.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Guillen C,Bartolomé A,Nevado C,Benito Mdoi
10.1016/j.febslet.2008.10.020subject
Has Abstractpub_date
2008-11-26 00:00:00pages
3855-60issue
28eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00838-7journal_volume
582pub_type
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