Aging decreases the abundance of retinoic acid (RAR) and triiodothyronine (TR) nuclear receptor mRNA in rat brain: effect of the administration of retinoids.

abstract：:Crosslinking of histones in mouse liver nuclei and extended chromatin with a bifunctional reagent leads to the formation of H1-H1o heterodimers as well as H1o-H1o homodimers. H1o can be also crosslinked to the core histones. Thus, the location of histone H1o within the basic repeating chromatin structure seems to be a...

journal_title：FEBS letters

authors： Dashkevich VK,Nikolaev LG,Zlatanova JS,Glotov BO,Severin ES

更新日期：1983-07-25 00:00:00

abstract：:For more than three decades, RNA recombination remained a puzzle and has only begun to be solved in the last few years. The available data provide evidence for a variety of RNA recombination mechanisms. Non-homologous recombination seems to be the most common for RNA. Recent experiments in both the in vitro and the in...

journal_title：FEBS letters

authors： Chetverin AB

更新日期：1999-10-22 00:00:00

abstract：:Steroids are of universal occurrence, present variously as cell wall constituents and bioregulators. A number of bacteria, fungi, and photosynthetic vascular plants synthesize steroids that are hormonally active in the animal world. The cellular effect of such steroids in microbes and plants appears by and large to be...

journal_title：FEBS letters

authors： Agarwal MK

更新日期：1993-05-17 00:00:00

abstract：:We have reported that histone deacetylase (HDAC) inhibitors activate a member of the INK4 family, the p19INK4d gene, causing G1 phase arrest. We report here that HDAC inhibitor, Trichostatin A, activates another member of the INK4 family, the p18INK4c gene, through its promoter in Jurkat cells. Interestingly, the acti...

journal_title：FEBS letters

authors： Yokota T,Matsuzaki Y,Sakai T

更新日期：2004-09-10 00:00:00

abstract：:Here, we used a reductant, N-acetyl-L-cysteine (NAC), to investigate the redox-sensitive step(s) in the signalling pathway from the tumor necrosis factor (TNF) receptor to nuclear factor kappaB (NF-kappaB). We found that NAC suppressed NF-kappaB activation triggered by TNF or by overexpression of either the TNF recept...

journal_title：FEBS letters

authors： Oka S,Kamata H,Kamata K,Yagisawa H,Hirata H

更新日期：2000-04-28 00:00:00

abstract：:Chimeric proteins composed of ricin toxin A chain (RTA) and staphylococcal protein A (PA) have been produced in E. coli. Constructs consisting of N-terminal RTA and C-terminal PA (RTA-PA) or N-terminal PA and C-terminal (PA-RTA) were capable of binding to immunoglobulin G (via PA) and of specifically depurinating 28 S...

journal_title：FEBS letters

authors： O'Hare M,Brown AN,Hussain K,Gebhardt A,Watson G,Roberts LM,Vitetta ES,Thorpe PE,Lord JM

更新日期：1990-10-29 00:00:00

abstract：:We performed microarray and computational gene network analyses to identify the detailed mechanisms by which sodium butyrate (SB) induces cell growth arrest and the differentiation of mouse colonic epithelial MCE301 cells. Two thousand six hundred four differentially expressed probe sets were identified in the cells t...

journal_title：FEBS letters

authors： Tabuchi Y,Takasaki I,Doi T,Ishii Y,Sakai H,Kondo T

更新日期：2006-05-29 00:00:00

abstract：:The NusB protein is involved in transcriptional regulation in bacteriophage lambda. NusB binds to the RNA form of the nut site and along with N, NusA, NusE and NusG, stabilizes the RNA polymerase transcription complex and allows stable, persistent antitermination. NusB contains a 10 residue Arg-rich RNA-binding motif ...

journal_title：FEBS letters

authors： Altieri AS,Mazzulla MJ,Zhou H,Costantino N,Court DL,Byrd RA

更新日期：1997-09-29 00:00:00

abstract：:Galanin mediates diverse physiological functions in digestive, endocrine, and central nervous systems through G-protein-coupled receptors. Two galanin receptors have been cloned but the gene structures are unknown. We report genomic and cDNA cloning of the mouse GalR1 galanin receptor and demonstrate that the coding s...

journal_title：FEBS letters

authors： Wang S,He C,Maguire MT,Clemmons AL,Burrier RE,Guzzi MF,Strader CD,Parker EM,Bayne ML

更新日期：1997-07-14 00:00:00

abstract：:SV40 large T antigen is phosphorylated at up to ten different amino acids clustered in an N-terminal and a C-terminal part of the polypeptide chain. The N-terminal phosphorylated residues include Ser 123 and Thr 124. We have analyzed the oligomerization, the complex formation with the cellular oncoprotein p53 and the ...

journal_title：FEBS letters

authors： Montenarh M,Müller D

更新日期：1987-09-14 00:00:00

abstract：:We identified cDNAs coding for homologues to tetrapod prion proteins (PrPs) in Atlantic salmon (Salmo salar) and Japanese pufferfish (Fugu rubripes), which were termed 'similar to PrPs' (stPrPs). Besides significant sequence homologies the fish stPrPs display characteristic structural features in common with tetrapod ...

journal_title：FEBS letters

authors： Oidtmann B,Simon D,Holtkamp N,Hoffmann R,Baier M

更新日期：2003-03-13 00:00:00

abstract：:Depletion of mitochondrial DNA (mtDNA) causes defects in respiratory activity and energy production. Recent studies have shown mitochondria to exist primarily as reticular networks, having tubular cristae. Using fluorescence microscopy and transmission electron microscopy, we have examined mitochondrial morphology and...

journal_title：FEBS letters

authors： Gilkerson RW,Margineantu DH,Capaldi RA,Selker JM

更新日期：2000-05-26 00:00:00

abstract：:Tyrosyl radicals can catalyze LDL oxidation. In addition to their LDL oxidizing ability, superoxide (O2.-)/nitric oxide (NO.) generate phenoxyl radicals when reacting with tyrosine. Therefore we tested if tyrosine can act as a pro-oxidant in O2.-/NO.-initiated LDL oxidation. When LDL was exposed to O2.-/NO., tyrosine ...

journal_title：FEBS letters

authors： Kapiotis S,Hermann M,Held I,Mühl A,Gmeiner B

更新日期：1997-06-09 00:00:00

abstract：:A rapid and highly efficient method of purifying the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides has been developed. This method relies upon a six-histidine affinity tag fused to the C-terminus of subunit I, which confers to the oxidase a high affinity for Ni(2+)-nitrilotriacetic acid (NTA) agarose. The...

journal_title：FEBS letters

authors： Mitchell DM,Gennis RB

更新日期：1995-07-10 00:00:00

abstract：:The role of Na+/H+ exchange in protein kinase C-mediated effects in platelets was investigated by studying the effect of removal of extracellular Na+ ([Na+]e) on the different responses induced by phorbol 12-myristate 13-acetate (PMA) and 1,2-dioctanoylglycerol (diC8). None of the responses studied, namely, protein ph...

journal_title：FEBS letters

authors： Krishnamurthi S,Patel Y,Morgan WA,Wheeler-Jones CP,Kakkar VV

更新日期：1989-07-31 00:00:00

abstract：:SV40 large tumor-antigen (T-ag) nuclear import is enhanced by the protein kinase CK2 (CK2) site (Ser111Ser112) flanking the nuclear localization sequence (NLS). Here we use site-directed mutagenesis to examine the influence of negative charge and conformation at the site on T-ag nuclear import and recognition by the N...

journal_title：FEBS letters

authors： Xiao CY,Jans P,Jans DA

更新日期：1998-12-04 00:00:00

abstract：:The interferon inducible transmembrane (IFITM) proteins mediate several cellular processes such as homotypic cell adhesion functions of interferons (IFNs) and cellular anti-proliferative activities. We show that the BAF complex-mediated induction of IFITM3 is dependent on binding of the transcriptional enhancer factor...

journal_title：FEBS letters

authors： Cuddapah S,Cui K,Zhao K

更新日期：2008-01-23 00:00:00

abstract：:In cultured rat pituitary gonadotrophs, gonadotropin-releasing hormone (GnRH) induces rapid hyperpolarization of the cell membrane and causes cessation of the spontaneous electrical activity present in non-stimulated cells. This initial response to GnRH is followed by slow oscillations of membrane potential (Vm) which...

journal_title：FEBS letters

authors： Kukuljan M,Stojilković SS,Rojas E,Catt KJ

更新日期：1992-04-13 00:00:00

abstract：:Four 12.2-12.6 kDa small heat-shock proteins (sHSPs) of Caenorhabditis elegans are the smallest known members of the sHSP family. They essentially comprise the characteristic C-terminal 'alpha-crystallin domain' of the sHSPs, having a very short N-terminal region, and lacking a C-terminal tail. Recombinant Hsp12.2 and...

journal_title：FEBS letters

authors： Kokke BP,Leroux MR,Candido EP,Boelens WC,de Jong WW

更新日期：1998-08-21 00:00:00

abstract：:Platelet release products and purified platelet-derived growth factor stimulated the phosphorylation of ribosomal protein S6 in cultured mouse Balb/c 3T3 fibroblasts. The post-nuclear fraction of the stimulated cells was enriched in S6 kinase activity specific for sites resembling those phosphorylated within intact ce...

journal_title：FEBS letters

authors： Wettenhall RE,Chesterman CN,Walker T,Morgan FJ

更新日期：1983-10-03 00:00:00

abstract：:Expression of calcyclin in different cell lines and mouse tissues was determined with polyclonal antibodies raised against calcyclin from Ehrlich ascites tumour (EAT) cells. The protein was detected in mouse skeletal and cardiac muscle, in lung, kidney and spleen, and was especially enriched in mouse smooth muscle as ...

journal_title：FEBS letters

authors： Kuźnicki J,Filipek A,Heimann P,Kaczmarek L,Kamińska B

更新日期：1989-08-28 00:00:00

abstract：:Elongation factors EF-G and EF-Tu are structural homologues and share near-identical binding sites on the ribosome, which encompass the GTPase-associated centre (GAC) and the sarcin-ricin loop (SRL). The SRL is fixed structure in the ribosome and contacts elongation factors in the vicinity of their GTP-binding site. I...

journal_title：FEBS letters

authors： Sergiev PV,Bogdanov AA,Dontsova OA

更新日期：2005-10-24 00:00:00

abstract：:The lateral diffusion of BK(Ca) channels was previously shown to be highly 'confined' in the COS-7 cell membrane. Here we report that the diffusion coefficient and the confinement area of BK(Ca) channel were significantly increased by the treatment of latrunculin A, an actin-depolymerizing agent, but not by microtubul...

journal_title：FEBS letters

authors： Won S,Lee BC,Park CS

更新日期：2011-07-21 00:00:00

abstract：:Regulation of acetylcholine receptor (AChR) gene expression was analyzed in alpha-bungarotoxin (alpha-BTX) treated rats. A reduction in available 125I-alpha-BTX binding sites was accompanied by an increase in the various AChR transcripts. The increase in the AChR alpha-, beta- epsilon- and delta-subunit mRNAs was simi...

journal_title：FEBS letters

authors： Asher O,Provenzano C,Fuchs S

更新日期：1991-05-06 00:00:00

abstract：:All acetylcholine receptor subunit genes contain E boxes and are blocked by membrane depolarization. We have used transfected C2C12 myogenic cells to investigate the response, to electrical stimulation and KCl, of wildtype and mutant regulatory regions of the chick acetylcholine receptor alpha, gamma and delta subunit...

journal_title：FEBS letters

authors： Su CT,Huang CF,Schmidt J

更新日期：1995-06-12 00:00:00

abstract：:The interactions between clavulanate and three class C enzymes have been studied in detail. In all cases, the reactions followed branched pathways where 25-150 turnovers occurred before inactivation was completed. Reactivation rates were quite low. The poor efficiency of clavulanate as a class C inactivator appeared t...

journal_title：FEBS letters

authors： Monnaie D,Frere JM

更新日期：1993-11-22 00:00:00

abstract：:Co-expression of the two genes encoding the alpha- and beta-subunit of the Thermoplasma acidophilum thermosome in Escherichia coli yielded fully assembled hetero-oligomeric complexes (alpha+beta). Surprisingly, also separate expression of both genes resulted in formation of hexadecameric complexes (alpha, beta) in the...

journal_title：FEBS letters

authors： Waldmann T,Nitsch M,Klumpp M,Baumeister W

更新日期：1995-11-27 00:00:00

abstract：:Two phosphoenolpyruvate carboxylase (PEPC) kinase genes (PPCk1 and PPCk2) are present in the Arabidopsis genome; only PPCk1 is expressed in rosette leaves. Homozygous lines of two independent PPCk1 T-DNA-insertional mutants showed very little (dln1), or no (csi8) light-induced PEPC phosphorylation and a clear retard i...

journal_title：FEBS letters

authors： Meimoun P,Gousset-Dupont A,Lebouteiller B,Ambard-Bretteville F,Besin E,Lelarge C,Mauve C,Hodges M,Vidal J

更新日期：2009-05-19 00:00:00

abstract：:The aim of the present research was to analyze the pathways for phosphatidic acid metabolism in purified nuclei from liver. Lipid phosphate phosphatase, diacylglycerol lipase, monoacylglycerol lipase and PA-phospholipase type A activities were detected. The presence of lysophosphatidic acid significantly reduced DAG p...

journal_title：FEBS letters

authors： Gaveglio VL,Pasquaré SJ,Giusto NM

更新日期：2013-04-02 00:00:00

abstract：:The serine peptidases, thrombocytin and PA-BJ, isolated from the venom of Bothrops atrox and Bothrops jararaca, respectively, induce platelet aggregation and granule secretion without clotting fibrinogen. The specific platelet aggregation activity of each enzyme was about 15 times lower than that of thrombin. This act...

journal_title：FEBS letters

authors： Santos BF,Serrano SM,Kuliopulos A,Niewiarowski S

更新日期：2000-07-21 00:00:00