Abstract:
:Regulation of acetylcholine receptor (AChR) gene expression was analyzed in alpha-bungarotoxin (alpha-BTX) treated rats. A reduction in available 125I-alpha-BTX binding sites was accompanied by an increase in the various AChR transcripts. The increase in the AChR alpha-, beta- epsilon- and delta-subunit mRNAs was similar to that observed in rats with experimental autoimmune myasthenia gravis (EAMG). Unlike in EAMG, the gamma-subunit transcripts reappeared following alpha-BTX treatment. The quantitative differences in the levels of AChR transcripts between alpha-BTX treatment and EAMG on one hand and denervation on the other hand, support the notion that the regulation of AChR gene expression is controlled by muscle activity and by neuronal factors as well. We also demonstrate in this report that myogenin transcripts increase following alpha-BTX treatment as well as following denervation, whereas MyoD1 transcripts remain stable.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Asher O,Provenzano C,Fuchs Sdoi
10.1016/0014-5793(91)80487-nkeywords:
subject
Has Abstractpub_date
1991-05-06 00:00:00pages
242-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(91)80487-Njournal_volume
282pub_type
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