Regulation of acetylcholine receptor gene expression in rats treated with alpha-bungarotoxin.

Abstract:

:Regulation of acetylcholine receptor (AChR) gene expression was analyzed in alpha-bungarotoxin (alpha-BTX) treated rats. A reduction in available 125I-alpha-BTX binding sites was accompanied by an increase in the various AChR transcripts. The increase in the AChR alpha-, beta- epsilon- and delta-subunit mRNAs was similar to that observed in rats with experimental autoimmune myasthenia gravis (EAMG). Unlike in EAMG, the gamma-subunit transcripts reappeared following alpha-BTX treatment. The quantitative differences in the levels of AChR transcripts between alpha-BTX treatment and EAMG on one hand and denervation on the other hand, support the notion that the regulation of AChR gene expression is controlled by muscle activity and by neuronal factors as well. We also demonstrate in this report that myogenin transcripts increase following alpha-BTX treatment as well as following denervation, whereas MyoD1 transcripts remain stable.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Asher O,Provenzano C,Fuchs S

doi

10.1016/0014-5793(91)80487-n

keywords:

subject

Has Abstract

pub_date

1991-05-06 00:00:00

pages

242-6

issue

2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(91)80487-N

journal_volume

282

pub_type

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