Abstract:
:The interactions between clavulanate and three class C enzymes have been studied in detail. In all cases, the reactions followed branched pathways where 25-150 turnovers occurred before inactivation was completed. Reactivation rates were quite low. The poor efficiency of clavulanate as a class C inactivator appeared to rest upon a very slow acylation of the protein, and of a relatively high turnover rate.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Monnaie D,Frere JMdoi
10.1016/0014-5793(93)80692-nsubject
Has Abstractpub_date
1993-11-22 00:00:00pages
269-71issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(93)80692-Njournal_volume
334pub_type
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