Abstract:
:The cytosolic lipid peroxidation product 4-hydroxynonenal (HNE) is rapidly metabolized in mitochondria isolated from rat kidney cortex. About 80% of HNE was degraded within 3 min of incubation. Main products of HNE which were identified in mitochondria were the hydroxynonenoic acid, the 1,4-dihydroxynonene and the glutathione-HNE-conjugate. Furthermore, formation of metabolites of the tricarboxylic acid cycle from HNE is suggested. The quantitative share of HNE binding to proteins was high with about 8% of total HNE consumption after 3 min of incubation. Therefore, rapid degradation of HNE by mitochondria might be involved in an intracellular antioxidative defense system.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ullrich O,Grune T,Henke W,Esterbauer H,Siems WGdoi
10.1016/0014-5793(94)00922-8subject
Has Abstractpub_date
1994-09-19 00:00:00pages
84-6issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(94)00922-8journal_volume
352pub_type
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