Abstract:
:Criteria for the design of peptide vaccines to prevent AIDS are presented. The best vaccine candidates contain both B and T lymphocyte-defined epitopes in regions conserved in sequence between viral isolates. We propose that attention should focus on proteins specified by the gag and, possibly, pol genes in addition to the env gene envelope glycoproteins being actively studied. The predictions of B- and T-epitopes are refined by consideration of secondary structure prediction and inter-isolate sequence variability to suggest peptides from env, gag and pol that would be the best vaccine candidates.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sternberg MJ,Barton GJ,Zvelebil MJ,Cookson J,Coates ARdoi
10.1016/0014-5793(87)81052-9subject
Has Abstractpub_date
1987-06-29 00:00:00pages
231-7issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(87)81052-9journal_volume
218pub_type
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