Lanthanum ions inhibit the mammalian Sec61 complex in its channel dynamics and protein transport activity.

abstract：:Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress. The ER stress sensor inositol requiring enzyme-1beta (IRE1β), which is specifically expressed in intestinal epithelial cells, is thought to be involved in translational repression. However, its mechanism of action is not fully unders...

journal_title：FEBS letters

authors： Nakamura D,Tsuru A,Ikegami K,Imagawa Y,Fujimoto N,Kohno K

更新日期：2011-01-03 00:00:00

abstract：:Novel peptides containing the sequence -Pro-Leu-Ama(NHOH)- were synthesized and characterized by spectroscopic techniques. Their inhibitory properties towards the activated form of native human gelatinase B (MMP-9) and the catalytic domain of neutrophil collagenase (cdMMP-8) were determined. The most effective inhibit...

journal_title：FEBS letters

authors： Krumme D,Wenzel H,Tschesche H

更新日期：1998-10-02 00:00:00

abstract：:The integrin alpha IIb beta 3-mediated redistribution of the tyrosine kinases pp125FAK and pp60Src and the small GTP-binding proteins CDC42Hs and Rap1B from the membrane skeleton to the cytoskeleton was found to be reversible: upon prolonged platelet aggregation (up to 15 min) induced by the thrombin-receptor activati...

journal_title：FEBS letters

authors： Dash D,Aepfelbacher M,Siess W

更新日期：1995-04-24 00:00:00

abstract：:Almost all eukaryotic mRNAs acquire a poly(A) tail at the 3'-end by a concerted RNA processing event: cleavage and polyadenylation. The canonical PAP, PAPα, was considered the only nuclear PAP involved in general polyadenylation of mRNAs. A phosphoinositide-modulated nuclear PAP, Star-PAP, was then reported to regulat...

journal_title：FEBS letters

authors： Laishram RS

更新日期：2014-06-27 00:00:00

abstract：:A steady-state framework was applied to the ubiquitous tricyclic enzyme cascade structure, as seen in the mitogen-activated protein (MAP) kinase system, to analyze the effect of upstream kinase concentrations on final output response. The results suggest that signal amplification achieved by the cascade structure ensu...

journal_title：FEBS letters

authors： Mutalik VK,Singh AP,Edwards JS,Venkatesh KV

更新日期：2004-01-30 00:00:00

abstract：:The dual function of the regulatory beta-subunit of protein kinase CK2 is highlighted by its ability to abolish calmodulin phosphorylation in contrast to its stimulatory effect on the phosphorylation of peptide substrates. Here we show that a synthetic peptide reproducing the C-terminal region of the beta-subunit (bet...

journal_title：FEBS letters

authors： Marin O,Meggio F,Boldyreff B,Issinger OG,Pinna LA

更新日期：1995-04-17 00:00:00

abstract：:In fibrous connective tissues, fibroblasts are organized into syncytia, cellular networks that enable matrix remodeling and that are interconnected by intercellular adherens junctions (AJs). The AJs of fibroblasts are mediated by N-cadherin, a broadly expressed classical cadherin that is critically involved in develop...

journal_title：FEBS letters

authors： El Sayegh TY,Kapus A,McCulloch CA

更新日期：2007-01-23 00:00:00

abstract：:The capacity of incomplete segments of Escherichia coli lactose permease to form transport-competent complexes in vivo was further tested. Two series of mutant lacY genes were constructed. One encoded N-terminal lactose permease segments of different length. The proteins specified by the other group contained deletion...

journal_title：FEBS letters

authors： Wrubel W,Stochaj U,Ehring R

更新日期：1994-08-08 00:00:00

abstract：:A phylogenetic analysis, using the open reading frame I sequence of 93 TT viruses (TTV) obtained from various geographical areas, indicated that the virus could be classified into six different genotypes including three hitherto unreported genotypes. The high reliability of the six clusters was confirmed by bootstrap ...

journal_title：FEBS letters

authors： Tanaka Y,Mizokami M,Orito E,Ohno T,Nakano T,Kato T,Kato H,Mukaide M,Park YM,Kim BS,Ueda R

更新日期：1998-10-23 00:00:00

abstract：:1H-NMR spectroscopy has been applied to identify components in the urine of subjects with a deficiency of the enzyme 3-hydroxy-3-methylglutaryl-CoA lyase. One-dimensional spectra of samples from a pair of non-identical twins with this disorder were very similar and are probably diagnostic. The most intense signals wer...

journal_title：FEBS letters

authors： Iles RA,Jago JR,Williams SR,Chalmers RA

更新日期：1986-07-14 00:00:00

abstract：:We report the cDNA-deduced primary structure of the chicken counterpart of the murine dilute gene product, a member of the myosin I family. Comparison of the chicken and mouse sequences reveals a distinct pattern of domains of high and low sequence conservation. An internal deletion of 25 amino acids probably reflects...

journal_title：FEBS letters

authors： Sanders G,Lichte B,Meyer HE,Kilimann MW

更新日期：1992-10-26 00:00:00

abstract：:Streptomyces lividans 1326-9, a bldA+ strain, and its bldA39 mutant derivative J1725 were transformed with a cosmid containing the pur cluster, which determines the puromycin biosynthetic pathway from Streptomyces alboniger. bldA+ transformants produced puromycin in typical amounts, whereas bldA39 transformants did so...

journal_title：FEBS letters

authors： Tercero JA,Espinosa JC,Jiménez A

更新日期：1998-01-16 00:00:00

abstract：:The urokinase receptor (uPAR) on the cell surface plays an important role in extracellular proteolysis, cell migration and adhesion. Soluble uPAR (suPAR) has been recently discovered in plasma, but its origin is unclear. Our results now demonstrate that both unstimulated blood mononuclear and endothelial cells can rel...

journal_title：FEBS letters

authors： Mustjoki S,Sidenius N,Vaheri A

更新日期：2000-12-15 00:00:00

abstract：:We report a new member of the von Willebrand factor A-domain protein superfamily, WARP (for von Willebrand factor A-domain-related protein). The full-length mouse WARP cDNA is 2.3 kb in size and predicts a protein of 415 amino acids which contains a signal sequence, a VA-like domain, two fibronectin type III-like repe...

journal_title：FEBS letters

authors： Fitzgerald J,Tay Ting S,Bateman JF

更新日期：2002-04-24 00:00:00

abstract：:MDNCF is a human monocyte-derived, 72-residue chemotactic peptide, which has sequence similarity with members of a family of pro-inflammatory cytokines. The peptide was synthesized by the solid-phase method, and is identical to the natural peptide in amino acid composition, sequence and chemotactic potency. MDNCF form...

journal_title：FEBS letters

authors： Tanaka S,Robinson EA,Yoshimura T,Matsushima K,Leonard EJ,Appella E

更新日期：1988-08-29 00:00:00

abstract：:Tert-butyl hydroperoxide (BHP), hydrogen peroxide and diamide caused a rapid and simultaneous release of glutathione disulfide (GSSG) and K+ in the isolated perfused rat liver. Both BHP-induced effluxes were suppressed by prior depletion of hepatic glutathione, but not by co-infusion of desferrioxamine which prevented...

journal_title：FEBS letters

authors： Masuda Y,Ozaki M,Aoki S

更新日期：1993-11-08 00:00:00

abstract：:Oxysterols result from cholesterol by enzymatic or oxidative processes. Some exert cytotoxic effects leading to necrosis or apoptosis. Detoxification of these compounds mainly occurs in the liver and requires transport from peripheral tissues towards it. Some ATP-binding cassette transporters are involved in export of...

journal_title：FEBS letters

authors： Engel T,Kannenberg F,Fobker M,Nofer JR,Bode G,Lueken A,Assmann G,Seedorf U

更新日期：2007-04-17 00:00:00

abstract：:Streptococcus pneumoniae (pneumococcus) has evolved sophisticated strategies to survive in several niches within the human body either as a harmless commensal or as a serious pathogen causing a variety of diseases. The dynamic interaction between pneumococci and resident host cells during colonization of the upper res...

journal_title：FEBS letters

authors： Kohler S,Voß F,Gómez Mejia A,Brown JS,Hammerschmidt S

更新日期：2016-11-01 00:00:00

abstract：:Syntenin has crucial roles in cell adhesion, cell migration and synaptic transmission. Its closely linked postsynaptic density-95, discs large 1, zonula occludens-1 (PDZ) domains typically interact with C-terminal ligands. We profile syntenin PDZ1-2 through proteomic peptide phage display (ProP-PD) using a library tha...

journal_title：FEBS letters

authors： Garrido-Urbani S,Garg P,Ghossoub R,Arnold R,Lembo F,Sundell GN,Kim PM,Lopez M,Zimmermann P,Sidhu SS,Ivarsson Y

更新日期：2016-01-01 00:00:00

abstract：:The human pathogen Vibrio vulnificus undergoes phase variation among colonial morphotypes, including a virulent opaque form which produces capsular polysaccharide (CPS) and a translucent phenotype that produces little or no CPS and is attenuated. Here, we found that a V. vulnificus mutant defective for RfaH antitermin...

journal_title：FEBS letters

authors： Garrett SB,Garrison-Schilling KL,Cooke JT,Pettis GS

更新日期：2016-12-01 00:00:00

abstract：:Many biochemical reactions are confined to interfaces, such as membranes or cell walls. Despite their importance, no canonical rate laws describing the kinetics of surface-active enzymes exist. Combining the approach chosen by Michaelis and Menten 100 years ago with concepts from surface chemical physics, we here pres...

journal_title：FEBS letters

authors： Kartal O,Ebenhöh O

更新日期：2013-09-02 00:00:00

abstract：:The transmission of receptor-generated cytoplasmic Ca2+ signals between communicating pancreatic acinar cells has been investigated by comparing patch-clamp recordings of Ca(2+)-dependent Cl- current in internally perfused single cells and small multi-cell clusters. Acetylcholine (50 nM) generates shortlasting repetit...

journal_title：FEBS letters

authors： Petersen CC,Petersen OH

更新日期：1991-06-17 00:00:00

abstract：:The effects of mastoparan on phospholipase C-catalysed phosphoinositide hydrolysis were examined in [3H]inositol-labelled human neuroblastoma SH-SY5Y cells. [3H]Inositol phosphate formation in intact cells was not altered by 20 microM mastoparan. In contrast, [3H]inositol phosphate formation in electrically permeabili...

journal_title：FEBS letters

authors： Wojcikiewicz RJ,Nahorski SR

更新日期：1989-04-24 00:00:00

abstract：:Temperature-induced order/disorder transition profiles were obtained from the membranes of intact Gram-negative bacterial cells by FT-IR analysis of the frequency shifts of the acyl chain methylene symmetric stretching band as a monitor. Cells grown at different temperatures yielded distinct transition profiles. At th...

journal_title：FEBS letters

authors： Schultz C,Naumann D

更新日期：1991-12-02 00:00:00

abstract：:In photosystem II (PSII) the probability that energy absorbed by core antenna chlorophyll (Chl) is transferred to the reaction center (RC) is extremely high. Although close proximity between antenna Chl ensures a high transfer efficiency, relative pigment orientation can fractionally modify it. This level of refinemen...

journal_title：FEBS letters

authors： Vasil'ev S,Shen JR,Kamiya N,Bruce D

更新日期：2004-03-12 00:00:00

abstract：:We have reconstituted thin filaments comprising pyrene-labelled actin (pyr-actin), tropomyosin (Tm) and cardiac troponin (cTn). cTn was isolated in two defined phosphorylation states; completely dephosphorylated on all subunits and with only the cTnI subunit bisphosphorylated. The thin filament was saturated with cTn ...

journal_title：FEBS letters

authors： Reiffert SU,Jaquet K,Heilmeyer LM Jr,Ritchie MD,Geeves MA

更新日期：1996-04-08 00:00:00

abstract：:The human H19 gene is a paternally imprinted oncofetal gene, highly expressed in several fetal tissues, down-regulated in nearly all adult tissues but re-expressed in carcinomas of tissues which express the gene in fetal life. It has no known protein product and till today, no function could be designated to H19 RNA. ...

journal_title：FEBS letters

authors： Ohana P,Kopf E,Bibi O,Ayesh S,Schneider T,Laster M,Tykocinski M,de Groot N,Hochberg A

更新日期：1999-07-02 00:00:00

abstract：:RNA binding motif protein 5 (RBM5) is a candidate tumor suppressor gene. Recent studies showed that RBM5 functions as an alternative splicing regulator of apoptosis-related genes. Here, we identify DHX15 and PRP19, two spliceosome components, as novel RBM5-interacting partners. We then show that the G-patch domain of ...

journal_title：FEBS letters

authors： Niu Z,Jin W,Zhang L,Li X

更新日期：2012-04-05 00:00:00

abstract：:We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM. STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c-myc induction mediated by IL-2 and GM-CSF. Co-expression of the SH3 deletion mutants of STAM1 and STAM2 ...

journal_title：FEBS letters

authors： Endo K,Takeshita T,Kasai H,Sasaki Y,Tanaka N,Asao H,Kikuchi K,Yamada M,Chenb M,O'Shea JJ,Sugamura K

更新日期：2000-07-14 00:00:00

abstract：:Myeloma cells specifically localize in the bone marrow and rarely circulate in blood. To study whether this immobilization could be partially explained by the presence of constitutively activated integrins, particularly alpha4beta1, we used the activation reporter HUTS-21 anti-beta1 mAb. These analyses showed that bet...

journal_title：FEBS letters

authors： García-Gila M,Cabañas C,García-Pardo A

更新日期：1997-12-01 00:00:00