Abstract:
:The transmission of receptor-generated cytoplasmic Ca2+ signals between communicating pancreatic acinar cells has been investigated by comparing patch-clamp recordings of Ca(2+)-dependent Cl- current in internally perfused single cells and small multi-cell clusters. Acetylcholine (50 nM) generates shortlasting repetitive spikes of Ca(2+)-dependent current and these spikes are not transmitted to neighbouring cells. Cholecystokinin octapeptide (5 pM) also generates repetitive spikes, but a significant proportion of these trigger longer and larger pulses of Ca(2+)-dependent current and these waves can easily spread from cell to cell. In pancreatic acinar units it is therefore possible to observe both local Ca2+ signals confined to the cell of its origin as well as Ca2+ signals that spread through communicating junctions to all cells in the unit.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Petersen CC,Petersen OHdoi
10.1016/0014-5793(91)80774-wkeywords:
subject
Has Abstractpub_date
1991-06-17 00:00:00pages
113-6issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(91)80774-Wjournal_volume
284pub_type
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