Receptor-activated cytoplasmic Ca2+ spikes in communicating clusters of pancreatic acinar cells.

Abstract:

:The transmission of receptor-generated cytoplasmic Ca2+ signals between communicating pancreatic acinar cells has been investigated by comparing patch-clamp recordings of Ca(2+)-dependent Cl- current in internally perfused single cells and small multi-cell clusters. Acetylcholine (50 nM) generates shortlasting repetitive spikes of Ca(2+)-dependent current and these spikes are not transmitted to neighbouring cells. Cholecystokinin octapeptide (5 pM) also generates repetitive spikes, but a significant proportion of these trigger longer and larger pulses of Ca(2+)-dependent current and these waves can easily spread from cell to cell. In pancreatic acinar units it is therefore possible to observe both local Ca2+ signals confined to the cell of its origin as well as Ca2+ signals that spread through communicating junctions to all cells in the unit.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Petersen CC,Petersen OH

doi

10.1016/0014-5793(91)80774-w

keywords:

subject

Has Abstract

pub_date

1991-06-17 00:00:00

pages

113-6

issue

1

eissn

0014-5793

issn

1873-3468

pii

0014-5793(91)80774-W

journal_volume

284

pub_type

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