Abstract:
:We report a new member of the von Willebrand factor A-domain protein superfamily, WARP (for von Willebrand factor A-domain-related protein). The full-length mouse WARP cDNA is 2.3 kb in size and predicts a protein of 415 amino acids which contains a signal sequence, a VA-like domain, two fibronectin type III-like repeats, and a short proline- and arginine-rich segment. WARP mRNA was expressed predominantly in chondrocytes and in vitro expression experiments in transfected 293 cells indicated that WARP is a secreted glycoprotein that forms disulphide-bonded oligomers. We conclude that WARP is a new member of the von Willebrand factor A-domain (VA-domain) superfamily of extracellular matrix proteins which may play a role in cartilage structure and function.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fitzgerald J,Tay Ting S,Bateman JFdoi
10.1016/s0014-5793(02)02579-6keywords:
subject
Has Abstractpub_date
2002-04-24 00:00:00pages
61-6issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579302025796journal_volume
517pub_type
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