Abstract:
:To better understand the mechanisms involved in the developmental expression of Trypanosoma cruzi antigens we examined the gene structure and transcription properties of the major shed trypomastigote antigen (SAPA). We report in this paper that SAPA is encoded by a small family of at lest 6 genes which differ mainly in the length of a repeat region made up of tandemly arranged 36-bp repeat units. SAPA genes are located distant from chromosomal telomeres as inferred from their insensitivity to Bal31 nuclease treatment. Furthermore, Northern blot and S1 protection analyses strongly support the fact that most (or all) SAPA genes are transcribed in the infective form of the parasite.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Affranchino JL,Pollevick GD,Frasch ACdoi
10.1016/0014-5793(91)80320-3subject
Has Abstractpub_date
1991-03-25 00:00:00pages
316-20issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(91)80320-3journal_volume
280pub_type
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