Abstract:
:Nucleoside modifications in tRNA anticodons regulate ribosome dynamics during translation elongation and, thereby, fine-tune global protein synthesis rates. The highly conserved eukaryotic Elongator complex conducts specific C5-substitutions in tRNA wobble base uridines. It harbors two copies of each of its six individual subunits, which are all equally important for its activity. Here, we summarize recent developments focusing on the architecture of the Elongator complex, showing an asymmetric subunit arrangement, and its functional implications. In addition, we discuss the role of its proposed active site, its individual subunits and temporarily associated regulatory factors. Finally, we aim to provide mechanistic explanations for the link between mutations in Elongator subunits and the onset of several severe human pathologies.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Dauden MI,Jaciuk M,Müller CW,Glatt Sdoi
10.1002/1873-3468.12865subject
Has Abstractpub_date
2018-02-01 00:00:00pages
502-515issue
4eissn
0014-5793issn
1873-3468journal_volume
592pub_type
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