Abstract:
:The WWE domain is often identified in proteins associated with ubiquitination or poly-ADP-ribosylation. Structural information about WWE domains has been obtained for the ubiquitination-related proteins, such as Deltex and RNF146, but not yet for the poly-ADP-ribose polymerases (PARPs). Here we determined the solution structures of the WWE domains from PARP11 and PARP14, and compared them with that of the RNF146 WWE domain. NMR perturbation experiments revealed the specific differences in their ADP-ribose recognition modes that correlated with their individual biological activities. The present structural information sheds light on the ADP-ribose recognition modes by the PARP WWE domains.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
He F,Tsuda K,Takahashi M,Kuwasako K,Terada T,Shirouzu M,Watanabe S,Kigawa T,Kobayashi N,Güntert P,Yokoyama S,Muto Ydoi
10.1016/j.febslet.2012.09.009subject
Has Abstractpub_date
2012-11-02 00:00:00pages
3858-64issue
21eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00716-8journal_volume
586pub_type
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