Structural insight into the interaction of ADP-ribose with the PARP WWE domains.

Abstract:

:The WWE domain is often identified in proteins associated with ubiquitination or poly-ADP-ribosylation. Structural information about WWE domains has been obtained for the ubiquitination-related proteins, such as Deltex and RNF146, but not yet for the poly-ADP-ribose polymerases (PARPs). Here we determined the solution structures of the WWE domains from PARP11 and PARP14, and compared them with that of the RNF146 WWE domain. NMR perturbation experiments revealed the specific differences in their ADP-ribose recognition modes that correlated with their individual biological activities. The present structural information sheds light on the ADP-ribose recognition modes by the PARP WWE domains.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

He F,Tsuda K,Takahashi M,Kuwasako K,Terada T,Shirouzu M,Watanabe S,Kigawa T,Kobayashi N,Güntert P,Yokoyama S,Muto Y

doi

10.1016/j.febslet.2012.09.009

subject

Has Abstract

pub_date

2012-11-02 00:00:00

pages

3858-64

issue

21

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(12)00716-8

journal_volume

586

pub_type

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