Abstract:
:We have previously demonstrated that the taurine uptake and transporter (TAUT) mRNA expression were upregulated by tumor necrosis factor alpha (TNF-alpha) in Caco-2 cells. In this present study, the signaling molecules related to this upregulation were investigated. Pyrrolidine dithiocarbamate, a nuclear factor kappaB (NF-kappaB) inhibitor, repressed the upregulation of taurine uptake and TAUT mRNA expression. A reporter assay revealed that TNF-alpha-induced TAUT transcriptional activity through the NF-kappaB consensus-like sequence in the human TAUT promoter region. An electrophoretic mobility shift assay showed that NF-kappaB could bind to the NF-kappaB consensus-like sequence. The anti-TNF receptor 1 (TNFR1) antibody, but not the TNF receptor 2 (TNFR2) antibody, repressed this upregulation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mochizuki T,Satsu H,Shimizu Mdoi
10.1016/j.febslet.2005.04.063keywords:
subject
Has Abstractpub_date
2005-06-06 00:00:00pages
3069-74issue
14eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00540-5journal_volume
579pub_type
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