Abstract:
:APE-independent base excision repair (BER) pathway plays an important role in the regulation of DNA repair mechanisms. In this study it has been found that recently discovered tyrosyl-DNA phosphodiesterase 1 (Tdp1) catalyzes the AP site cleavage reaction to generate breaks with the 3'- and 5'-phosphate termini. The removal of the 3'-phosphate is performed by polynucleotide kinase phosphatase (PNKP). Tdp1 is known to interact stably with BER proteins: DNA polymerase beta (Pol β), XRCC1, PARP1 and DNA ligase III. The data suggest a role of Tdp1 in the new APE-independent BER pathway in mammals.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lebedeva NA,Rechkunova NI,Lavrik OIdoi
10.1016/j.febslet.2011.01.032subject
Has Abstractpub_date
2011-02-18 00:00:00pages
683-6issue
4eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00062-7journal_volume
585pub_type
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