Abstract:
:The in vivo responses of pyruvate dehydrogenase (PDH) complex to starvation and insulin was assessed in heart, diaphragm and red quadriceps muscle. PDH complex activity was decreased by starvation (3.4-10.2-fold), the magnitude of change depending on muscle type. Insulin increased PDH activity in all muscle types. In fed rats, this effect was relatively small (1.25-1.29-fold). In starved rats there were effects in heart (4.3-fold) and red quadriceps (1.7-fold) but no effect in diaphragm. These results demonstrate that PDH complex in different groups of muscle has different insulin sensitivity (particularly in tissues from starved animals).
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Denyer GS,Lam D,Cooney GJ,Caterson IDdoi
10.1016/0014-5793(89)80777-xsubject
Has Abstractpub_date
1989-07-03 00:00:00pages
464-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(89)80777-Xjournal_volume
250pub_type
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