Abstract:
:PDZ domains are thought to act as protein-binding modules mediating the clustering of membrane and membrane-associated proteins. The INAD protein has been shown to interact via a PDZ domain with the calcium channel TRP which contributes to capacitative calcium entry into Drosophila photoreceptor cells. We have cloned the cDNA of a human INAD-Like protein (hINADL) of 1524 amino acids in length containing at least five PDZ domains. Additionally, two truncated versions hINADL(delta304) and hINADL(delta853) were identified. hInadl transcripts of differing size are expressed in various tissues including brain, where transcripts are abundant in the cerebellum.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Philipp S,Flockerzi Vdoi
10.1016/s0014-5793(97)00877-6subject
Has Abstractpub_date
1997-08-18 00:00:00pages
243-8issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(97)00877-6journal_volume
413pub_type
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