Abstract:
:SigT is an ECF sigma factor in Streptomyces coelicolor. sigT and its putative anti-sigma factor gene rstA are located in one putative operon, and SigT could physically interact with RstA. Deletion of sigT or rstA caused accelerated morphological development and enhanced production of antibiotics, concomitant with over-expression of chpE, chpH, actII-orf4 and redD. Furthermore, SigT was undetectable after loss of rstA. These data suggested that SigT has a negative role on differentiation and that RstA negatively regulates the SigT activity through a putative antagonistic mechanism and at the post-transcriptional level.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mao XM,Zhou Z,Cheng LY,Hou XP,Guan WJ,Li YQdoi
10.1016/j.febslet.2009.09.025subject
Has Abstractpub_date
2009-10-06 00:00:00pages
3145-50issue
19eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00713-3journal_volume
583pub_type
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