Abstract:
:Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane protein concentrated in plasma membrane protrusions. In epithelial cells, notably neuroepithelial stem cells, prominin-1 is found in microvilli, the primary cilium and the midbody. These three types of apical membrane protrusions are subject to remodeling during (neuro)epithelial cell differentiation. The protrusion-specific localization of prominin involves its association with a distinct cholesterol-based membrane microdomain. Moreover, the three prominin-1-containing plasma membrane protrusions are the origin of at least two major subpopulations of prominin-1-containing extracellular membrane particles. Intriguingly, the release of these particles has been implicated in (neuro)epithelial cell differentiation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Corbeil D,Marzesco AM,Wilsch-Bräuninger M,Huttner WBdoi
10.1016/j.febslet.2010.01.050subject
Has Abstractpub_date
2010-05-03 00:00:00pages
1659-64issue
9eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00083-9journal_volume
584pub_type
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