Abstract:
:MRL mice bearing the lpr (Fas) or gld (Fas ligand) mutation, MRL-Fas(lpr) or MRL-FasL(gld), respectively, develop arthritis similar to rheumatoid arthritis, but C3H and C57BL/6 mice bearing such mutations do not. In MRL-Fas(lpr) mice, agalactosylated oligosaccharides in serum IgG increase significantly in comparison to MRL-+/+ mice without arthritis. In this study, an increased level of agalactosylation in IgG, as compared to MRL-+/+, was found in both MRL-Fas(lpr) and MRL-FasL(gld) mice. In contrast, the incidence of IgG without galactose was comparable among C3H-Fas(lpr), C3H-FasL(gld), and C3H-+/+ mice as well as between C57BL/6-Fas(lpr) and C57BL/6-+/+ mice. These results suggest that the increase in agalactosylated IgG and the development of arthritis in MRL-Fas(lpr) and MRL-FasL(gld) mice are controlled by the MRL genetic background.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kuroda Y,Nakata M,Nose M,Kojima N,Mizuochi Tdoi
10.1016/s0014-5793(01)02974-xkeywords:
subject
Has Abstractpub_date
2001-10-26 00:00:00pages
210-4issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(01)02974-Xjournal_volume
507pub_type
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