Abstract:
:PTPRO is often silenced by DNA hypermethylation in primary human tumors and cancer cell lines and functions as a tumor suppressor. Here we show that PTPRO is a target of E2F1. In addition, the microRNA cluster miR-17-92, another target of E2F1, participates in PTPRO regulation. PTPRO mRNA was up-regulated during S phase in synchronized HeLa cells and in vitro PTPRO promoter activity is high in early S phase while the PTPRO 3'UTR reporter activity is low in late S phase. This study provides evidence that the PTPRO gene is co-regulated by both E2F1 and miR-17-92.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Xu X,Hong Y,Kong C,Xu L,Tan J,Liang Q,Huang B,Lu Jdoi
10.1016/j.febslet.2008.07.017subject
Has Abstractpub_date
2008-08-20 00:00:00pages
2850-6issue
19eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00597-8journal_volume
582pub_type
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