Abstract:
:Phosphate triester derivatives of the anti-neoplastic alkyl lyso phospholipid (ALP) have been prepared as novel potential therapeutic agents. In particular, symmetrical phosphate triesters have been prepared, using phosphorochloridate chemistry. The compounds have been fully characterised by a range of techniques, and assayed for their inhibition of DNA synthesis by mammalian cells in culture. The compounds are generally inhibitory towards DNA synthesis in the microM range. However, the magnitude of the effect varies greatly with the phosphate structure; alkynyl and glycol substituted phosphates being especially potent.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
McGuigan C,Wang Y,Riley PAdoi
10.1016/0014-5793(95)00959-dsubject
Has Abstractpub_date
1995-09-25 00:00:00pages
259-63issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(95)00959-Djournal_volume
372pub_type
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