Abstract:
:Amyloid-beta peptide (Abeta), the major constituent of senile plaques in the Alzheimer's disease (AD) brain, is the main source of oxidative stress leading to neurodegeneration. The methionine residue in this peptide is reported to be responsible for neurotoxicity. Structurally similar substitution with methionine 35 replaced by cysteine in Abeta(40) was synthesized, and this result in enhanced beta-sheet structures according to both circular dichroism (CD) spectra and beta-fibril specific fluorescence assay but attenuated cytotoxicity whether in the presence of copper or not. These findings may provide further evidence on disclosing the connection between amyloid beta-aggregation and Abeta-induced neurotoxicity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Dai XL,Sun YX,Jiang ZFdoi
10.1016/j.febslet.2007.02.038subject
Has Abstractpub_date
2007-04-03 00:00:00pages
1269-74issue
7eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00204-9journal_volume
581pub_type
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