Abstract:
:Ca(2+) channels that underlie mitochondrial Ca(2+) transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca(2+) uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca(2+) transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca(2+) overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca(2+) channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca(2+) channels.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ryu SY,Beutner G,Dirksen RT,Kinnally KW,Sheu SSdoi
10.1016/j.febslet.2010.01.032subject
Has Abstractpub_date
2010-05-17 00:00:00pages
1948-55issue
10eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00055-4journal_volume
584pub_type
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