Abstract:
:Lung surfactant secretion is a highly regulated process. Our previous studies have shown that VAMP-2 is essential for surfactant secretion. In the present study we investigated the role of miR-206 in surfactant secretion through VAMP-2. VAMP-2 was confirmed to be a target of miR-206 by 3'-untranslational region (3'-UTR) luciferase assay. Mutations in the predicated miR-206 binding sites reduced the binding of miR-206 to the 3'-UTR of VAMP-2. miR-206 decreased the expression of VAMP-2 protein and decreased the lung surfactant secretion in alveolar type II cells. In conclusion, miR-206 regulates lung surfactant secretion by limiting the availability of VAMP-2 protein.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Zhang H,Guo Y,Mishra A,Gou D,Chintagari NR,Liu Ldoi
10.1016/j.febslet.2014.11.043subject
Has Abstractpub_date
2015-01-02 00:00:00pages
172-6issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00859-Xjournal_volume
589pub_type
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