Abstract:
:Oligonucleotide-peptide conjugates have several applications, including their potential use as improved antisense agents for interfering with the RNA function within cells. In order to provide robust and generally applicable conjugation chemistry, we developed a novel approach of fragment coupling of pre-synthesized peptides to the 2'-position of a selected nucleotide within an otherwise protected oligonucleotide chain attached to a solid support.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Zubin EM,Romanova EA,Volkov EM,Tashlitsky VN,Korshunova GA,Shabarova ZA,Oretskaya TSdoi
10.1016/s0014-5793(99)00921-7keywords:
subject
Has Abstractpub_date
1999-07-30 00:00:00pages
59-62issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00921-7journal_volume
456pub_type
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