Abstract:
:The effects of metal cations on the activation of recombinant human SK4 (also known as hIK1 or hKCa4) channels, expressed in HEK 293 cells, were tested using patch clamp recording. Of the nine metals tested, cobalt, iron, magnesium, and zinc did not activate the SK4 channels when applied, at concentrations up to 100 microM, to the inside of SK4 channel-expressing membrane patches. Barium, cadmium, calcium, lead, and strontium activated SK4 channels in a concentration-dependent manner. The rank order of potency was at Ca2+ > Pb2+ > Cd2+ > Sr2+ > Ba2+.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Cao YJ,Houamed KMdoi
10.1016/s0014-5793(99)00194-5keywords:
subject
Has Abstractpub_date
1999-03-05 00:00:00pages
137-41issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00194-5journal_volume
446pub_type
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