Abstract:
:The aim of this investigation was to study the effect of intramitochondrial acyl-CoA on the respiration of rabbit heart mitochondria over the whole range of stationary respiratory rates between States 4 and 3. The creatine phosphokinase system was used for stabilization of extramitochondrial adenine nucleotide concentration. It was shown that acyl-CoA depressed respiration more effectively in the intermediate range of respiration between States 4 and 3. The effect of acyl-CoA was negligible near State 4 and in State 3. These data are in line with our previous results concerning the dependence of the adenine nucleotide translocator control coefficient on the rate of mitochondrial respiration. Thus, our data suggest that long-chain acyl-CoA may regulate oxidative phosphorylation in heart mitochondria in vivo.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Borutaite V,Mildaziene V,Ivanoviene L,Kholodenko B,Toleikis A,Praskevicius Adoi
10.1016/0014-5793(89)80141-3subject
Has Abstractpub_date
1989-01-30 00:00:00pages
264-6issue
2eissn
0014-5793issn
1873-3468journal_volume
243pub_type
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