Abstract:
:This work describes the molecular cloning of a variant isoform of the low-affinity levocabastine-sensitive neurotensin receptor isolated from mouse brain. Although the corresponding mRNA encodes for a 282 amino acid protein unable to bind neurotensin after transient transfection in COS-7 cells, this non-functional neurotensin receptor is expressed in cerebral neocortex, cerebellum, olfactory bulb, striatum and hypothalamus with a level similar to that of the full-length low-affinity neurotensin receptor. By contrast, this receptor form is very weakly expressed in mesencephalon and absent in the pituitary, but is the major product in the spinal cord.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Botto JM,Sarret P,Vincent JP,Mazella Jdoi
10.1016/s0014-5793(96)01391-9subject
Has Abstractpub_date
1997-01-03 00:00:00pages
211-4issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(96)01391-9journal_volume
400pub_type
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